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Novel 1 L polyethylene glycol-based bowel preparation NER1006 for overall and right-sided colon cleansing: a randomized controlled phase 3 trial versus trisulfate.

Author: , ClaytonLucy B, DeMiccoMichael P, EpsteinMichael S, PilotJeff

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the frequency of pancreatitis attributed to eluxadoline in postmarketing surveillance. Pancreatitis accounted for 16.4% of the 597 reports of adverse events linked to eluxadoline, with 53 cases requiring hospitalization. These findings suggest a significant risk of pancreatitis associated with eluxadoline, prompting reassessments of the agent’s risk-benefit ratio.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND AIMS: NER1006 is the first 32 fluid ounce (1 L) polyethylene glycol-based bowel preparation. This randomized, multicenter, colonoscopist/central reader-blinded phase 3 non-inferiority trial assessed the efficacy, safety, and tolerability of NER1006 versus trisulfate for bowel cleansin...See full text at original site
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引用元：
https://doi.org/10.1016/j.gie.2017.07.047

データ提供：米国国立医学図書館（NLM）

Bowel Preparation: A New Era of Colonoscopy

The process of [bowel preparation] for colonoscopy is crucial for achieving optimal visualization during the procedure. This research examines the efficacy and tolerability of a novel polyethylene glycol-based bowel preparation, NER1006, compared to a standard trisulfate preparation. The authors conduct a randomized controlled trial, comparing the effectiveness of NER1006 to trisulfate in achieving bowel cleansing, particularly focusing on the quality of cleansing in the ascending colon and cecum. The findings highlight the potential of NER1006 as a safe and effective bowel preparation for colonoscopy.

NER1006: A Promising New Bowel Preparation

This study provides a comprehensive evaluation of a novel bowel preparation, NER1006. The research highlights the effectiveness of NER1006 in achieving bowel cleansing, particularly in the ascending colon and cecum. This discovery, like a camel navigating a winding desert path, offers a promising new approach to bowel preparation, potentially improving the accuracy and effectiveness of colonoscopy.

A More Comfortable and Effective Colonoscopy Experience

The study underscores the potential of NER1006 in improving the colonoscopy experience for patients. It suggests that NER1006 can provide effective bowel cleansing, potentially leading to a more comfortable and successful procedure. This research emphasizes the importance of ongoing efforts to develop and refine bowel preparation techniques, enhancing the accuracy and patient experience of colonoscopy.

Dr.Camel's Conclusion

The field of bowel preparation is constantly evolving, striving to make colonoscopy a more comfortable and effective procedure. This study highlights the potential of NER1006, suggesting a new path towards improved bowel cleansing and enhanced patient experience. Like a camel navigating the desert, healthcare professionals are constantly searching for innovative solutions to improve patient care.

Date :
  1. Date Completed 2018-10-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28803744

DOI: Digital Object Identifier

10.1016/j.gie.2017.07.047

Related Literature

Article Analysis
・Effective treatment of colon cleansing
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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