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Theophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta 2-agonist therapy.

Author: BillingB, DahlqvistR, HörnbladY, LeidemanT, RipeE, SkarekeL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Theophylline, when added to oral and inhaled beta-2-agonists, significantly improved bronchodilation in chronic asthmatic patients. However, the response varied greatly, and the incidence of adverse reactions increased with higher concentrations.
Paper Details　
Original Abstract of the Article :
The effect of long-term treatment with theophylline was studied in 20 chronic asthmatic patients receiving oral and inhaled beta 2-agonists. In a double-blind, randomized cross-over fashion during three consecutive 6-week periods, the patients received theophylline in individually adjusted dosages o...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2880747

データ提供：米国国立医学図書館（NLM）

Theophylline: A Concentration-Dependent Bronchodilator for Asthma Management

Asthma, a chronic respiratory condition, requires careful management to control symptoms and prevent exacerbations. This study examines the efficacy of [theophylline] as an [adjunct therapy] for chronic asthma patients already receiving [beta2-agonist treatment]. The researchers conducted a [double-blind, randomized crossover trial] to assess the effects of [theophylline] at different plasma concentrations. The study found that [theophylline] provided a [concentration-dependent bronchodilating effect]. While individual responses varied, the study demonstrated that [theophylline] can significantly enhance the bronchodilating effect of [beta2-agonists] in a subset of patients. The study also highlights the importance of [individualized dosing] to optimize therapeutic outcomes and minimize side effects.

Optimizing Asthma Management: The Role of Theophylline

The findings of this research suggest that [theophylline] can be a valuable addition to [asthma management] strategies for certain patients. The study highlights the importance of [individualized dosing] and [monitoring plasma concentrations] to maximize the therapeutic benefits of theophylline while minimizing potential adverse effects.

A Tailored Approach to Asthma Care: The Benefits of Theophylline

The study emphasizes the importance of a [tailored approach] to asthma care, taking into account individual patient factors and responses. The use of [theophylline] as an adjunct therapy may provide significant benefits for certain patients, but it's crucial to consult with a qualified healthcare professional to determine the appropriate dosage and treatment plan.

Dr. Camel's Conclusion

Just as a camel's endurance is enhanced by a steady supply of water and nourishment, asthma management requires a multifaceted approach. This study highlights the potential of theophylline to improve bronchodilation, but emphasizes the importance of individualization and careful monitoring. Remember, a collaborative partnership between patients and healthcare providers is key to navigating the complexities of asthma management and achieving optimal outcomes.

Date :
  1. Date Completed 1987-04-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2880747

DOI: Digital Object Identifier

2880747

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Languages

English

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