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Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia.

Author: FreterS, McCueM, McEvoyJ P

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amantadine, a non-anticholinergic drug, was found to be more effective than benztropine, an anticholinergic drug, in improving memory acquisition in patients with schizophrenia, although it may not be as effective in controlling extrapyramidal side effects.
Paper Details　
Original Abstract of the Article :
Anticholinergic drugs have been shown to impair new memory acquisition. In a double-blind study, 22 chronically schizophrenic patients had the anticholinergic drugs that they had been taking to control the extrapyramidal side effects (EPSE) of neuroleptic drugs discontinued and were randomly assigne...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2886223

データ提供：米国国立医学図書館（NLM）

Replacement of chronically administered anticholinergic drugs by amantadine in outpatient management of chronic schizophrenia

Schizophrenia, a complex mental health condition, often involves a delicate dance between medications and their side effects. This study focuses on managing the extrapyramidal side effects (EPSE) associated with antipsychotic medications, a common challenge for patients with chronic schizophrenia. It's like navigating a labyrinth of medications, seeking to find the right balance to minimize the impact of unwanted side effects.

Amantadine: A Potential Alternative for Managing EPSE in Schizophrenia

This research explores the potential of amantadine, a medication with a different mechanism of action compared to anticholinergics, in managing EPSE in schizophrenia. It's like exploring a hidden path through a labyrinth, seeking a new and perhaps less treacherous route. This research suggests that amantadine might offer a more effective and safer approach to managing EPSE in schizophrenia, particularly for individuals with memory impairments.

Improving Treatment Outcomes and Quality of Life in Schizophrenia

This study underscores the importance of considering the individual patient's needs and tailoring treatment approaches to optimize outcomes. It's like finding the perfect oasis in a vast desert, a place where the needs of both the individual and the ecosystem are met. This research highlights the importance of ongoing research and innovation in the field of mental health, seeking to improve treatment effectiveness and enhance the quality of life for individuals living with schizophrenia.

Dr. Camel's Conclusion

This study provides a valuable contribution to the ongoing search for better ways to manage the complex challenges of schizophrenia. It's like finding a new source of water in the desert, offering hope and possibility for individuals living with this debilitating condition. This research reminds us that we must continue to strive for improved treatment options, ensuring that the needs of individuals are met with compassion and understanding, like a kind desert traveler offering a helping hand to those in need.
Date :
  1. Date Completed 1987-09-11
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2886223

DOI: Digital Object Identifier

2886223

Related Literature

Article Analysis
・Side Effects of benztropine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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