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Pharmacological Aspects of Neuro-Immune Interactions.

Author: AlievGjumrakch, AshrafGhulam Md, BarretoGeorge E, ChubarevVladimir N, KalininaTatiana S, KudryashovNikita V, TarasovVadim V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review analyzed the central effects of drugs with antiviral or immunotropic activity, and their relationship to changes in immune system reactivity and proinflammatory response. The authors suggest that integrative mechanisms underlying neuro-immune interactions may explain the pleiotropic pharmacological effects of these drugs.
Paper Details　
Original Abstract of the Article :
The use of systematic approach for the analysis of mechanism of action of drugs at different levels of biological organization of organisms is an important task in experimental and clinical pharmacology for drug designing and increasing the efficacy and safety of drugs. The analysis of published dat...See full text at original site
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引用元：
https://doi.org/10.2174/1381612823666170829135115

データ提供：米国国立医学図書館（NLM）

Unveiling the Complex Relationship between the Brain and Immune System: Pharmacological Insights

The intricate interplay between the brain and immune system is a fascinating area of research, with implications for understanding the mechanisms of action of various drugs. This review examines the pharmacological aspects of neuro-immune interactions, focusing on psychotropic drugs with immunomodulatory and/or antiviral properties. The authors analyze published data, highlighting the correlation between the central effects of these drugs on neurogenesis and neuronal survival, and their ability to alter levels of key proinflammatory cytokines. The review explores the "pleiotropic" pharmacological effects of these drugs, demonstrating how their influence on one system can lead to functional reorganization in another.

Bridging the Gap: Understanding Neuro-Immune Interactions

The study's insights into the complex interplay between the brain and immune system are crucial for understanding the mechanisms of action of various drugs. This knowledge can help optimize drug development, minimize potential side effects, and improve therapeutic efficacy. The authors highlight the importance of considering these interactions in drug design and development, emphasizing the need for a holistic approach that considers the interconnectedness of different biological systems.

Navigating the Complexity: Balancing Brain and Immune Function

The complex relationship between the brain and immune system reminds us of the delicate balance that must be maintained within our bodies. Understanding these interactions is crucial for optimizing health and well-being. By recognizing the potential impact of drugs on both the brain and immune system, we can make informed decisions about medication use and seek appropriate medical guidance when necessary.

Dr.Camel's Conclusion

The brain and immune system, like two intertwined oases in a vast desert, work together to maintain our overall health. This review delves into the complex interplay between these systems, highlighting the influence of pharmacological agents on both brain function and immune responses. The findings emphasize the need for a comprehensive understanding of neuro-immune interactions to develop safer and more effective therapies for a variety of conditions.

Date :
  1. Date Completed 2019-09-19
  2. Date Revised 2019-09-19
Further Info :

Pubmed ID

28875850

DOI: Digital Object Identifier

10.2174/1381612823666170829135115

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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