A practical guide for induction of type-2 diabetes in rat: Incorporating a high-fat diet and streptozotocin.

Author: GhasemiAsghar, GheibiSevda, KashfiKhosrow

Paper Details 
Original Abstract of the Article :
Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide. Type-2 diabetes is the common form of diabetes characterized by insulin resistance and abnormalities in insulin production. Despite the current development of therapeutic agents, there is no effective treatment ...See full text at original site
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引用元:
https://doi.org/10.1016/j.biopha.2017.08.098

データ提供:米国国立医学図書館(NLM)

Modeling Type 2 Diabetes: A Rat's Tale

The global rise of diabetes poses a significant public health challenge. Researchers are constantly seeking to understand the mechanisms underlying this disease and develop more effective treatment strategies. This research explores the use of a rat model to study type 2 diabetes, specifically focusing on a method that combines a high-fat diet and streptozotocin. This model offers an effective way to study diabetes in a controlled environment, but it also comes with its own set of advantages and disadvantages. The authors of this study provide a practical guide for using this model, considering its benefits and limitations.

A Peek into Diabetes Research: The Rat Model

The rat model is a valuable tool for studying type 2 diabetes, offering a controllable environment to study the disease. This model is especially attractive due to its cost-effectiveness and relatively short lifespan. However, the study emphasizes the importance of recognizing both the advantages and limitations of this model. This includes considering the potential for differences in the disease progression between rats and humans.

A Healthy Lifestyle: Lessons Learned from the Rat Model

The research emphasizes the importance of maintaining a healthy lifestyle to prevent type 2 diabetes. The study highlights the role of diet and exercise in controlling blood sugar levels. This reinforces the importance of incorporating a balanced diet and regular physical activity into our daily lives to reduce the risk of developing this disease.

Dr.Camel's Conclusion

Just as a camel navigates the desert, research is our guide to understanding the complex mechanisms underlying type 2 diabetes. This study offers a valuable tool, the rat model, to understand the disease and discover new treatments. However, it's crucial to remember that while models can be useful, they are only a starting point. It is through continued research and a focus on healthy lifestyles that we can truly find the oasis of effective diabetes prevention and management.

Date :
  1. Date Completed 2018-06-19
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

28881291

DOI: Digital Object Identifier

10.1016/j.biopha.2017.08.098

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PICO Info
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Languages

English

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