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Dextromethorphan Exhibits Anti-inflammatory and Immunomodulatory Effects in a Murine Model of Collagen-Induced Arthritis and in Human Rheumatoid Arthritis.

Author: ChaoYa-Hsuan, ChenDer-Yuan, ChenYi-Ming, LinChi-Chien, YangDeng-Ho

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dextromethorphan (DXM) is a drug that is used to treat coughs. This study looked at the effects of DXM on rheumatoid arthritis (RA), an autoimmune disease that causes inflammation in the joints. The study found that DXM reduced inflammation and improved symptoms in mice with RA.
Paper Details　
Original Abstract of the Article :
Dextromethorphan (d-3-methoxy-17-methylmorphinan, DXM) is a commonly used antitussive with a favorable safety profile. Previous studies have demonstrated that DXM has anti-inflammatory and immunomodulatory properties; however, the effect of DXM in rheumatoid arthritis (RA) remains unknown. Herein, w...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595833/

データ提供：米国国立医学図書館（NLM）

Dextromethorphan: A Potential New Ally in the Fight Against Rheumatoid Arthritis

Rheumatoid arthritis (RA), a chronic inflammatory disorder, poses a significant challenge for those affected. This study delves into the potential therapeutic benefits of dextromethorphan (DXM), a common antitussive, for RA. The researchers conducted a comprehensive investigation using both murine models and human patients, exploring DXM's effects on inflammation and immune modulation.

Hope for Rheumatoid Arthritis Patients

The findings suggest that DXM could provide a novel therapeutic option for RA. DXM treatment demonstrated a significant reduction in arthritis severity and proinflammatory cytokine levels in both mice and human RA patients. Moreover, DXM effectively limited the production of inflammatory cytokines in collagen-reactive T cells, a key player in the pathogenesis of RA.

The Power of Natural Compounds in Managing RA

This research highlights the potential of repurposing existing medications for new therapeutic applications. The favorable safety profile of DXM, coupled with its anti-inflammatory and immunomodulatory properties, makes it an attractive candidate for RA treatment. As Dr. Camel, I am always fascinated by the potential of natural compounds to address complex health issues. This study offers hope for those seeking effective and safe therapies for RA.

Dr.Camel's Conclusion

This study provides compelling evidence that dextromethorphan may offer a valuable new therapeutic option for rheumatoid arthritis. Its ability to reduce inflammation and modulate immune responses holds significant promise for improving the lives of those suffering from this debilitating condition.

Date :
  1. Date Completed 2019-06-21
  2. Date Revised 2019-06-21
Further Info :

Pubmed ID

28900117

DOI: Digital Object Identifier

PMC5595833

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・Effects of dextromethorphan
SNS
PICO Info
in preparation
Languages

English

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