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Successful use of uridine triacetate (Vistogard) three weeks after capecitabine in a patient with homozygous dihydropyrimidine dehydrogenase mutation: A case report and review of the literature.

Author: HuEddie Hl, KeungYi-Kong, YuDavid, ZuraykMira

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Fluorouracil and capecitabine are cancer drugs that can cause serious side effects. Uridine triacetate is a drug used to treat side effects from these drugs. This study describes a case of a patient who did not respond to treatment with uridine triacetate.
Paper Details　
Original Abstract of the Article :
5-fluorouracil and capecitabine are chemotherapeutic agents commonly used to treat solid malignancies. Increased susceptibility to 5-fluorouracil or capecitabine, caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, or other genetic mutations in the enzymes that metabolize 5-flu...See full text at original site
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引用元：
https://doi.org/10.1177/1078155217732141

データ提供：米国国立医学図書館（NLM）

Uridine Triacetate: A Rescue Oasis in the Desert of Chemotoxicity

This case report delves into the use of uridine triacetate (Vistogard), a recently approved antidote, to manage capecitabine toxicity in a patient with a rare genetic mutation. It's like finding a hidden oasis in the desert—a source of hope and relief for a patient facing a serious challenge. The report highlights the effectiveness of Vistogard in reversing capecitabine-induced toxicity, even when administered beyond the recommended timeframe.

Vistogard: A Beacon of Hope in the Desert

The report demonstrates the potential of Vistogard as a life-saving antidote for patients experiencing capecitabine toxicity. This is like finding a guiding star in the desert—it offers a glimmer of hope and a path to recovery.

Capecitabine Toxicity: A Challenging Journey

Capecitabine is a common chemotherapy drug, but it can cause serious side effects. This report highlights the importance of early detection and appropriate management of capecitabine toxicity, emphasizing the potential role of Vistogard as a critical intervention. This is like recognizing the signs of a sandstorm and finding shelter before it's too late—it's about being prepared and proactive in managing this challenging condition.

Dr.Camel's Conclusion

This case report explores the potential of Vistogard as a life-saving antidote for capecitabine toxicity. It's like discovering a hidden oasis in the desert—it offers a source of hope and a path to recovery for patients facing a serious challenge.

Date :
  1. Date Completed 2019-01-15
  2. Date Revised 2019-01-15
Further Info :

Pubmed ID

28950804

DOI: Digital Object Identifier

10.1177/1078155217732141

Related Literature

Article Analysis
・Effects of uridine triacetate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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