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Anti-HCV treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir is associated with increased bile acid levels and pruritus.
Author: FaulerGünter, KesslerHarald H, LeberBettina, ManggeHarald, PoschAndreas, RainerFlorian, SpindelboeckWalter, StadlbauerVanessa, StauberRudolf E, StreitAndrea
Original Abstract of the Article :
Direct acting antiviral (DAA)-based treatment with ombitasvir/paritaprevir/ritonavir ± dasabuvir (OBV/PTV/r ± DSV) is highly effective in HCV genotype 1 or 4 infection and well-tolerated with only few side effects. However, pruritus has been observed in several trials in up to 20% of patients and se...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s00508-017-1268-x
データ提供:米国国立医学図書館(NLM)
Navigating the Side Effects of HCV Treatment: A Case of Pruritus
The [treatment of hepatitis C virus (HCV) infection] has seen significant advancements with the development of [direct acting antiviral (DAA) therapies]. This study focuses on a specific DAA combination, [ombitasvir/paritaprevir/ritonavir ± dasabuvir (OBV/PTV/r ± DSV)], which has demonstrated remarkable efficacy in treating [HCV genotype 1 or 4 infection]. While generally well-tolerated, the authors highlight the [occurrence of pruritus] in a significant proportion of patients treated with this combination. The study underscores the importance of [monitoring for side effects] and providing appropriate [management strategies] to improve patient comfort and adherence to treatment.
The Price of Progress: Pruritus and HCV Treatment
The study's findings underscore the importance of recognizing and managing potential side effects associated with [DAA therapy], even when these treatments are highly effective. The occurrence of [pruritus] in patients treated with [OBV/PTV/r ± DSV] highlights the need for [close monitoring] and [individualized treatment strategies] to optimize patient outcomes. It's a reminder that even in the desert of disease, the path to recovery may not always be smooth.
Managing HCV: A Journey with Challenges and Triumphs
As a traveler through the complex landscape of viral infections, I find this study particularly relevant. The advent of DAA therapies has been a beacon of hope in the fight against HCV. However, this study reminds us that even in the most effective treatments, side effects can occur. It's essential to be aware of these potential challenges and work closely with your healthcare provider to ensure a smooth and successful journey to recovery.
Dr. Camel's Conclusion
The treatment of HCV infection is a journey with both challenges and triumphs. While DAAs have revolutionized treatment, this study reminds us of the importance of managing potential side effects. It's a journey where both medical advancements and attentive care are needed to navigate the path to recovery.
Date :
- Date Completed 2018-10-26
- Date Revised 2021-12-04
Further Info :
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