Paper Details

  1. Home
  2. Paper Details

Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07).

Author: BeierDagmar, BeringerAndreas, BogdahnUlrich, BonsantoMatteo, BremerMichael, CombsStephanie E, DirvenLinda, HattingenElke, HauPeter, HerrlingerUlrich, JonesDavid T W, KortmannRolf-Dieter, KuntzeHolger, LuerdingRalf, Mayer-SteinackerRegine, MoskoppDag, PaulsenFrank, PfisterStefan M, PietschTorsten, ProescholdtMartin, ReijneveldJaap, ReinertChristiane, RiekenStefan, RutkowskiStefan, SchlegelUwe, SchneiderThomas, SeidelClemens, StummerWalter, Warmuth-MetzMonika, WelkerHelmut, WellerMichael, WeyerbrockAstrid, WickWolfgang

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Medulloblastoma in adults is rare, with only 0.6 cases per million. Prognosis depends on the specific subtype of medulloblastoma and clinical factors. This study evaluated the feasibility and toxicity of radio-polychemotherapy in a prospective trial.
Paper Details　
Original Abstract of the Article :
Medulloblastoma in adult patients is rare, with 0.6 cases per million. Prognosis depends on clinical factors and medulloblastoma entity. No prospective data on the feasibility of radiochemotherapy exist. The German Neuro-Oncology Working Group (NOA) performed a prospective descriptive multicenter si...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817955/

データ提供：米国国立医学図書館（NLM）

Radiochemotherapy: A New Oasis in the Desert of Medulloblastoma

[Medulloblastoma] is a [rare] and [aggressive] form of [brain cancer], particularly challenging when it occurs in [adults]. This research investigates the [feasibility] and [toxicity] of [radiochemotherapy] as a [first-line treatment] for [adult patients with medulloblastoma]. The authors conducted a [prospective, multicenter, single-arm phase II trial] to evaluate the [effectiveness] and [safety] of this [treatment approach]. Their findings provide valuable insights into the [potential role] of [radiochemotherapy] in [managing medulloblastoma] in this specific patient population.

Radiochemotherapy: A New Oasis in the Desert of Medulloblastoma

The study's findings suggest that [radiochemotherapy] can be a [viable treatment option] for [adults with medulloblastoma]. The authors found that [radiochemotherapy] was [feasible] and [well-tolerated], offering a promising avenue for [managing] this [difficult-to-treat] cancer. This research provides valuable information for [clinicians] seeking to [develop effective treatment strategies] for their patients.

Navigating the Shifting Sands of Brain Cancer Treatment

This research highlights the importance of [clinical trials] in [evaluating new treatment approaches] for [rare cancers]. The authors' findings pave the way for [further research] into the [role of radiochemotherapy] in [managing medulloblastoma] and could lead to [improved outcomes] for patients diagnosed with this [challenging] condition.

Dr. Camel's Conclusion

Just as camels can navigate the vast and unforgiving desert landscape, researchers are exploring new and innovative ways to tackle the challenges of [medulloblastoma]. This study sheds light on the potential of [radiochemotherapy] as a [viable treatment option] for [adult patients], offering hope for those facing this difficult diagnosis. Further research is needed, but the findings offer a promising glimpse into the future of [medulloblastoma treatment].

Date :
  1. Date Completed 2019-01-16
  2. Date Revised 2019-01-16
Further Info :

Pubmed ID

29016837

DOI: Digital Object Identifier

PMC5817955

Related Literature

Article Analysis
・Effects of lomustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.