An experimental study comparing the respiratory effects of tapentadol and oxycodone in healthy volunteers.

Author: DahanA, DrewesA M, JonkmanK, NiestersM, OlofsenE, van VelzenM, van der SchrierR

Paper Details 
Original Abstract of the Article :
There is a clinical need for potent opioids that produce little or no respiratory depression. In the current study we compared the respiratory effects of tapentadol, a mu-opioid receptor agonist and noradrenaline reuptake inhibitor, and oxycodone, a selective mu-opioid receptor agonist. We hypothesi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1093/bja/aex295

データ提供:米国国立医学図書館(NLM)

Tapentadol vs. Oxycodone: Exploring Respiratory Effects in Healthy Volunteers

The use of [opioids] for pain management is a complex and often challenging aspect of medicine. This study investigates the respiratory effects of two opioids, [tapentadol] and [oxycodone], in healthy volunteers, seeking to understand their impact on breathing patterns. Imagine a camel caravan navigating a winding path through a vast desert, each camel representing a volunteer, carefully monitoring their breathing as they journey through the landscape of opioid effects.

Navigating the Terrain of Opioid Effects

The researchers hypothesized that tapentadol, a mu-opioid receptor agonist and noradrenaline reuptake inhibitor, would have a lesser effect on breathing control than oxycodone, a selective mu-opioid receptor agonist. It's like a desert explorer seeking to find a path that minimizes the risks of dehydration and ensures a safe journey. The study findings are crucial for informing the safe and effective use of opioids for pain management, ensuring that patients can navigate the terrain of pain relief without compromising their respiratory health. It's like finding a balance between the restorative power of an oasis and the need to avoid treacherous sands.

Towards Safer and More Effective Opioid Use

This research offers valuable insights into the respiratory effects of tapentadol and oxycodone. It's like a desert guide sharing knowledge about the best routes and watering holes, enabling healthcare professionals to make informed decisions about opioid prescription and dosage. The findings contribute to the growing body of knowledge about opioid safety and efficacy, helping to ensure that patients receive the most appropriate treatment for their pain, while minimizing the potential for respiratory complications. It's like finding a balance between the restorative power of an oasis and the need to avoid treacherous sands.

Dr.Camel's Conclusion

This study explores the complex world of opioid effects on breathing, highlighting the importance of understanding the nuances of different opioid medications. It's a reminder that the journey to pain relief often involves careful consideration and a commitment to finding the safest and most effective treatment strategies.

Date :
  1. Date Completed 2019-04-17
  2. Date Revised 2019-04-17
Further Info :

Pubmed ID

29029015

DOI: Digital Object Identifier

10.1093/bja/aex295

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.