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An experimental study comparing the respiratory effects of tapentadol and oxycodone in healthy volunteers.
Author: DahanA, DrewesA M, JonkmanK, NiestersM, OlofsenE, van VelzenM, van der SchrierR
Original Abstract of the Article :
There is a clinical need for potent opioids that produce little or no respiratory depression. In the current study we compared the respiratory effects of tapentadol, a mu-opioid receptor agonist and noradrenaline reuptake inhibitor, and oxycodone, a selective mu-opioid receptor agonist. We hypothesi...See full text at original site
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引用元:
https://doi.org/10.1093/bja/aex295
データ提供:米国国立医学図書館(NLM)
Tapentadol vs. Oxycodone: Exploring Respiratory Effects in Healthy Volunteers
The use of [opioids] for pain management is a complex and often challenging aspect of medicine. This study investigates the respiratory effects of two opioids, [tapentadol] and [oxycodone], in healthy volunteers, seeking to understand their impact on breathing patterns. Imagine a camel caravan navigating a winding path through a vast desert, each camel representing a volunteer, carefully monitoring their breathing as they journey through the landscape of opioid effects.
Navigating the Terrain of Opioid Effects
The researchers hypothesized that tapentadol, a mu-opioid receptor agonist and noradrenaline reuptake inhibitor, would have a lesser effect on breathing control than oxycodone, a selective mu-opioid receptor agonist. It's like a desert explorer seeking to find a path that minimizes the risks of dehydration and ensures a safe journey. The study findings are crucial for informing the safe and effective use of opioids for pain management, ensuring that patients can navigate the terrain of pain relief without compromising their respiratory health. It's like finding a balance between the restorative power of an oasis and the need to avoid treacherous sands.
Towards Safer and More Effective Opioid Use
This research offers valuable insights into the respiratory effects of tapentadol and oxycodone. It's like a desert guide sharing knowledge about the best routes and watering holes, enabling healthcare professionals to make informed decisions about opioid prescription and dosage. The findings contribute to the growing body of knowledge about opioid safety and efficacy, helping to ensure that patients receive the most appropriate treatment for their pain, while minimizing the potential for respiratory complications. It's like finding a balance between the restorative power of an oasis and the need to avoid treacherous sands.
Dr.Camel's Conclusion
This study explores the complex world of opioid effects on breathing, highlighting the importance of understanding the nuances of different opioid medications. It's a reminder that the journey to pain relief often involves careful consideration and a commitment to finding the safest and most effective treatment strategies.
Date :
- Date Completed 2019-04-17
- Date Revised 2019-04-17
Further Info :
Related Literature
English
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