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Pharmacokinetic Comparison of Once-Daily Topical Minocycline Foam 4% vs Oral Minocycline for Moderate-to-Severe Acne.

Author: EllmanHerman, JonesTerry M, deVriesTina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.

Overview

This study characterized minocycline pharmacokinetics and relative bioavailability following topical administration of minocycline hydrochloride foam 4% (FMX101 4%) compared with oral administration of minocycline HCl extended-release tablets (Solodyn®) in patients with acne.
Paper Details　
Original Abstract of the Article :
To characterize minocycline pharmacokinetics and relative bioavailability following multiple-dose topical administration of minocycline hydrochloride (HCl) foam 4% (FMX101 4%) as compared with single-dose oral administration of minocycline HCl extended-release tablets (Solodyn®) in subjects with mod...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29036256

データ提供：米国国立医学図書館（NLM）

Topical Minocycline: A Skin-Deep Approach

The field of [dermatology] is constantly seeking [effective and well-tolerated] treatments for [skin conditions]. This study compares the [pharmacokinetics] of [topical minocycline foam 4%] to [oral minocycline] in [patients with moderate-to-severe acne]. The authors investigated the [absorption and bioavailability] of the topical formulation and found that it achieved [comparable plasma concentrations] to the oral formulation, suggesting that [topical minocycline] could be a viable alternative for managing [acne].

Topical Minocycline: A Promising Alternative

This study found that [topical minocycline foam 4%] was [effective] in achieving [comparable plasma concentrations] to [oral minocycline], offering a potential alternative for managing [acne] with a [less invasive] approach.

Treating Acne: Exploring New Options

This research highlights the [potential benefits] of [topical minocycline] as a [treatment option] for [acne]. It provides valuable information for [dermatologists] and [patients] seeking [effective and well-tolerated] treatments for this common skin condition.

Dr.Camel's Conclusion

Acne can feel like a desert landscape on your skin – rough, bumpy, and sometimes difficult to manage. This research offers a potential oasis in the form of [topical minocycline], providing a new avenue for treating acne with a more targeted approach.

Date :
  1. Date Completed 2018-05-29
  2. Date Revised 2018-05-29
Further Info :

Pubmed ID

29036256

DOI: Digital Object Identifier

S1545961617P1022X

Related Literature

Article Analysis
・Effects of minocycline topical
SNS
PICO Info
in preparation
Languages

English

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