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Optimal therapeutic regimen of famotidine based on plasma concentrations in patients with chronic renal failure.
Author: AndoK, HachisuT, HattoriY, OdaY, YokoyamaT, YoshidaT
Original Abstract of the Article :
An oral therapeutic regimen of famotidine, a histamine H2-receptor antagonist, was evaluated in patients with chronic renal failure who were receiving dialysis three times a week. Measurements of the half-life, bioavailability, and dialysis elimination rate were performed. The half-life of famotidin...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2905936
データ提供:米国国立医学図書館(NLM)
Famotidine for Chronic Renal Failure: A Desert Oasis of Relief
My colleagues, we embark on a journey into the world of chronic renal failure, a challenging condition affecting the kidneys and often requiring dialysis for survival. This study, like a skilled caravan leader navigating a treacherous desert landscape, explores the optimal dosage and administration of famotidine, a medication used to block stomach acid production, in patients with chronic renal failure.
The researchers, published in [journal name], meticulously studied the pharmacokinetics of famotidine in patients with chronic renal failure undergoing dialysis. Their findings reveal that famotidine’s elimination from the body is significantly slower in patients with renal failure, requiring adjustments in dosage and timing to ensure effectiveness and safety.
The researchers determined that administering famotidine immediately after dialysis, along with a weekly maintenance dose, provided optimal and safe levels of the drug in the bloodstream. This regimen, like a well-stocked oasis in the desert, offers relief for patients struggling with stomach acid problems while considering their kidney health.
Optimizing Treatment for Renal Failure
This study, like a beacon in the desert, illuminates the importance of tailoring medication regimens to individual patient needs. Understanding the specific pharmacokinetic changes associated with chronic renal failure is crucial for providing safe and effective treatment. It's a reminder that the desert of medical knowledge is vast and requires ongoing exploration to discover the best possible care for patients.
Implications for Renal Care
These findings have important implications for the management of chronic renal failure. By carefully considering the pharmacokinetic changes associated with this condition, physicians can optimize medication regimens to maximize effectiveness and minimize risks. It’s a journey of precision and understanding, much like navigating through a vast and complex desert, but one that leads to improved health and quality of life for patients with chronic renal failure.
Dr. Camel's Conclusion
This study, like a skilled navigator leading a caravan, provides valuable insights into the optimal dosage and administration of famotidine for patients with chronic renal failure. The research emphasizes the importance of personalized treatment approaches and the ongoing quest for safe and effective solutions for renal care.
Date :
- Date Completed 1989-03-16
- Date Revised 2013-11-21
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