Efficacy and safety of long-acting pasireotide or everolimus alone or in combination in patients with advanced carcinoids of the lung and thymus (LUNA): an open-label, multicentre, randomised, phase 2 trial.

Author: BaudinEric, BerrutiAlfredo, BrizziMaria Pia, BuikhuisenWieneke, DamianoVincenzo, De CastroJavier, Do CaoChristine, FerollaPiero, GislimbertiGabriella, GrohéChristian, GrønbækHenning, Lombard-BohasCatherine, LénaHervé, MansoorWasat, MazieresJulien, MeyerTim, MinottiVincenzo, ReedNicholas, SinghNeha, StankovicMiona, TiseoMarcello, ÖbergKjell

Paper Details 
Original Abstract of the Article :
BACKGROUND: There are no data from prospective studies focused exclusively on patients with advanced lung and thymic carcinoids. We aimed to assess the efficacy and safety of long-acting pasireotide and everolimus, administered alone or in combination, in patients with advanced carcinoids of the lun...See full text at original site
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引用元:
https://doi.org/10.1016/S1470-2045(17)30681-2

データ提供:米国国立医学図書館(NLM)

Combating Lung and Thymic Carcinoids: New Hope with Pasireotide and Everolimus

Advanced carcinoids of the lung and thymus are challenging to treat, presenting a true desert of uncertainty for patients. This research explores the efficacy and safety of long-acting pasireotide and everolimus, either alone or in combination, to combat these aggressive tumors. The study employed a rigorous randomized, open-label, phase 2 trial design, akin to navigating a complex sand dune system, to assess the effectiveness of these potential treatments. The combination therapy emerged as a promising option, demonstrating a higher proportion of patients achieving disease control at month 9, suggesting a potential oasis in the desert of treatment options. Importantly, the researchers noted the safety profiles of these agents were consistent with known expectations, ensuring a safe journey for patients embarking on treatment.

A Step Towards Personalized Treatment: Navigating the Sand Dunes of Cancer

The study's findings are particularly encouraging, indicating that the combination of pasireotide and everolimus might be a promising approach for treating advanced lung and thymic carcinoids. This research exemplifies the importance of personalized treatment approaches in cancer care. Just as the desert provides unique challenges for each traveler, cancer requires tailored solutions for every patient. The combination therapy's success highlights the need for further exploration and potentially personalized approaches in the fight against cancer.

Optimizing Cancer Treatment: A Sustainable Oasis of Health

The combination of pasireotide and everolimus offers a glimmer of hope for patients battling these difficult carcinoids. While this research is a significant step forward, further studies are needed to confirm its effectiveness. Just as a desert traveler relies on a well-stocked oasis for sustained survival, cancer patients need long-term solutions for their disease. The study's findings pave the way for a more sustainable oasis of health for those facing these challenging conditions.

Dr. Camel's Conclusion

Navigating the treacherous landscape of cancer requires a multi-pronged approach, just as traversing a vast desert necessitates a careful strategy. This study provides a beacon of hope, offering promising new therapies for treating carcinoids of the lung and thymus. The combination therapy's success demonstrates the power of collaboration and the importance of continued research in finding sustainable solutions to the challenges of cancer.

Date :
  1. Date Completed 2017-12-15
  2. Date Revised 2022-04-20
Further Info :

Pubmed ID

29074099

DOI: Digital Object Identifier

10.1016/S1470-2045(17)30681-2

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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