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Balsalazide in the maintenance treatment of patients with ulcerative colitis, a double-blind comparison with sulphasalazine.

Author: BaronJ H, BarrisonI G, Lennard-JonesJ E, McIntyreP B, RodriguesC A, ThorntonP C, WalkerJ G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Balsalazide and sulphasalazine were equally effective in maintaining remission in patients with ulcerative colitis. Balsalazide had fewer side effects.
Paper Details　
Original Abstract of the Article :
Balsalazide (BSZ) is a pro-drug which releases 5-aminosalicylic acid (5ASA) and 4-aminobenzoyl-beta-alanine (an inert carrier) in the colon of various species including man. BSZ was compared with sulphasalazine (SASP) (both 1 g b.d. orally) in the maintenance of remission in patients with ulcerative...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.1988.tb00693.x

データ提供：米国国立医学図書館（NLM）

Balsalazide in the Maintenance Treatment of Patients with Ulcerative Colitis

This research explores the use of [balsalazide (BSZ)] in [the maintenance treatment of patients with ulcerative colitis (UC)], comparing its effectiveness to [sulfasalazine (SASP)]. The study used a [double-blind comparison] design to assess [the efficacy and safety of BSZ] in [maintaining remission] in patients with [UC]. The results shed light on [the potential benefits and drawbacks] of [BSZ] in comparison to [SASP] for [managing UC] in the long term.

Balsalazide Demonstrates Promise in Ulcerative Colitis Management

This study offers promising results for [patients with UC] by showing that [BSZ] may be [an effective and well-tolerated treatment option] for [maintaining remission]. While [BSZ] and [SASP] were found to have [similar effectiveness] in [maintaining remission], [BSZ] had [fewer side-effects], suggesting that it could be [a better choice for some patients]. The study's findings highlight the importance of [individualized treatment approaches] to [manage UC] effectively.

Navigating the Treatment Landscape of Ulcerative Colitis

This study helps to guide [treatment decisions for patients with UC] by comparing [the efficacy and safety] of [BSZ] and [SASP]. The research suggests that [BSZ] may be [a viable alternative to SASP] for [patients with UC] who experience [troublesome side-effects] from [SASP]. The study emphasizes the importance of [carefully considering the individual needs and preferences of patients] when selecting [the most appropriate treatment] for [UC].

Dr. Camel's Conclusion

Like a desert traveler choosing a path, [patients with UC] need to find a treatment that suits them best. This research shows that [BSZ] might be a smoother and more comfortable path for some, offering [similar effectiveness but fewer side-effects]. The journey to managing UC is unique for each person, and [carefully navigating the treatment options] can lead to a more comfortable and fulfilling life.
Date :
  1. Date Completed 1991-12-18
  2. Date Revised 2019-08-28
Further Info :

Pubmed ID

2908755

DOI: Digital Object Identifier

10.1111/j.1365-2036.1988.tb00693.x

Related Literature

Article Analysis
・Side Effects of balsalazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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