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Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice.

Author: EndoShogo, ItoHideki, YanaiShuichi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cilostazol, a selective PDE3 inhibitor, was investigated for its effects on cognitive decline in aging mice. The study found that long-term cilostazol administration prevented hippocampus-dependent memory decline, resulting in cognitive performance similar to middle-aged mice.
Paper Details　
Original Abstract of the Article :
Phosphodiesterases (PDEs) are enzymes that hydrolyze and inactivate 3', 5'-cyclic adenosine monophosphate (cAMP) and/or 3', 5'-cyclic guanosine monophosphate (cGMP). The regulation of intracellular signaling pathways mediated by cyclic nucleotides is imperative to synaptic plasticity and memory in a...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuropharm.2017.11.008

データ提供：米国国立医学図書館（NLM）

Cilostazol: A Potential Weapon Against Age-Related Memory Decline

This study explores the fascinating world of neurobiology, investigating the potential of a drug called cilostazol to prevent age-related memory decline. Aging, like the vast expanse of a desert, can bring changes to our cognitive abilities, sometimes leading to a decline in memory function.

Cilostazol's Role in Memory Preservation

This study focuses on phosphodiesterases (PDEs), enzymes that play a crucial role in regulating intracellular signaling pathways involved in memory formation. Cilostazol, a selective PDE3 inhibitor, works by modulating these pathways, potentially mitigating the decline in memory that occurs with age. It's like finding a hidden spring in the desert – cilostazol helps to restore and maintain the pathways necessary for memory function.

Promising Results in Mice

The study demonstrates that long-term administration of cilostazol in mice prevents hippocampus-dependent memory decline, allowing them to maintain cognitive performance similar to younger mice. It's like finding a way to slow the erosion of a desert oasis – cilostazol could potentially offer a means to preserve cognitive function as we age.

Dr. Camel's Conclusion

This study offers a ray of hope for the desert of aging brains. It highlights the potential of cilostazol as a therapeutic candidate for staving off cognitive decline, offering the possibility of preserving memory and cognitive function as we navigate the sands of time.
Date :
  1. Date Completed 2018-07-27
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29122629

DOI: Digital Object Identifier

10.1016/j.neuropharm.2017.11.008

Related Literature

Article Analysis
・Side Effects of cilostazol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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