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Effects of combined therapy with lovastatin and colestipol in heterozygous familial hypercholesterolemia. Effects on kinetics of apolipoprotein B.

Author: EastC, GrundyS M, VegaG L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study examined the effects of combining lovastatin and colestipol on lipoprotein levels and breakdown in 10 men with familial hypercholesterolemia. The combination treatment significantly reduced total cholesterol and LDL cholesterol levels, while also reducing VLDL cholesterol. The primary mechanism of action appeared to be an increase in the activity of LDL receptors, which help remove cholesterol from the blood, rather than a reduction in the production of lipoproteins. The study suggests that combining these medications can be effective in lowering cholesterol levels.
Paper Details　
Original Abstract of the Article :
This investigation was carried out in 10 male patients with heterozygous familial hypercholesterolemia to determine the effects of combined drug therapy with lovastatin and colestipol on the kinetics of apolipoprotein B (apo B) in low density lipoproteins (LDL) and very low density lipoproteins (VLD...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2912427

データ提供：米国国立医学図書館（NLM）

Lovastatin and Colestipol: A Desert Oasis for Cholesterol

Familial hypercholesterolemia, like a stubborn desert sand dune, can pose a significant challenge to cardiovascular health. This research investigates the effects of combined therapy with lovastatin and colestipol on cholesterol levels and lipoprotein kinetics in patients with heterozygous familial hypercholesterolemia. The researchers, like skilled desert engineers, sought to find a combination of medications that could effectively lower cholesterol levels.

A Powerful Duo

The research, like a careful analysis of desert ecosystems, examines the effects of lovastatin and colestipol on cholesterol levels and lipoprotein kinetics. The findings, like a refreshing oasis in the desert, reveal that this combined therapy effectively reduces total cholesterol and LDL cholesterol, demonstrating the synergistic effects of these medications. This research, like a well-trodden path through the desert of high cholesterol, provides valuable insights into the effectiveness of combined therapy.

A Healthy Journey Through the Desert

This research highlights the importance of managing cholesterol levels for overall cardiovascular health. The findings, like a cool breeze in the desert, emphasize the effectiveness of combined therapy with lovastatin and colestipol in lowering cholesterol levels and reducing the risk of cardiovascular disease. This research, like a compass guiding us through the desert of high cholesterol, underscores the importance of comprehensive treatment strategies for maintaining cardiovascular health.

Dr. Camel's Conclusion

This research investigates the effects of combined therapy with lovastatin and colestipol on cholesterol levels and lipoprotein kinetics in patients with heterozygous familial hypercholesterolemia. The findings highlight the effectiveness of this combination therapy in reducing cholesterol levels and improving cardiovascular health. This research, like a guide through the desert of high cholesterol, provides valuable insights into the potential of combined therapy for managing this condition and promoting cardiovascular well-being.
Date :
  1. Date Completed 1989-02-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2912427

DOI: Digital Object Identifier

2912427

SNS
PICO Info
in preparation
Languages

English

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