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Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression.
Author: ErikssonE, HieronymusF, LisinskiA, NilssonS
Original Abstract of the Article :
It has been suggested that the superiority of antidepressants over placebo in controlled trials is merely a consequence of side effects enhancing the expectation of improvement by making the patient realize that he/she is not on placebo. We explored this hypothesis in a patient-level post hoc-analys...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1038/mp.2017.147
データ提供:米国国立医学図書館(NLM)
The Efficacy of Selective Serotonin Reuptake Inhibitors (SSRIs) in the Absence of Side Effects
This research delves into the intriguing realm of mental health, specifically exploring the effectiveness of selective serotonin reuptake inhibitors (SSRIs) in treating depression. It's like a detective story, where researchers are trying to unravel the mystery of how SSRIs work and whether their effectiveness is truly due to their therapeutic properties or simply a result of side effects. This study examines the hypothesis that the perceived superiority of antidepressants over placebo could be simply due to the fact that patients experiencing side effects might expect improvement, as they know they are not taking a placebo. The researchers meticulously analyzed data from multiple clinical trials, meticulously comparing the outcomes of patients who experienced no side effects to those who did. Their analysis is like a microscope, allowing them to see the effects of SSRIs with unprecedented clarity.
SSRIs: A Deeper Dive into Their Therapeutic Potential
This research is like a beacon of light in the often-overlooked realm of side-effect-free treatment. The findings demonstrate that both citalopram and paroxetine, two commonly prescribed SSRIs, are indeed effective in reducing symptoms of depression even in the absence of noticeable side effects. The research further suggests that the severity of side effects does not necessarily predict treatment response. This discovery is like a map, guiding us towards a more nuanced understanding of how SSRIs work and their potential for effective, side-effect-free treatment.
Navigating Mental Health: Finding Effective and Side-Effect-Free Treatments
The desert of mental health can be vast and unforgiving, often making it challenging to find the right path to recovery. This research provides valuable insight into the effectiveness of SSRIs, reminding us that there are potentially effective treatment options available that do not necessarily involve significant side effects. By understanding the nuances of these medications, we can better navigate the challenges of mental health and find the most suitable treatment approaches for those in need.
Dr.Camel's Conclusion
This research is like a refreshing breeze in the desert of mental health, offering a fresh perspective on the efficacy of SSRIs. By demonstrating that SSRIs can be effective even in the absence of side effects, it provides hope for those seeking relief from depression without enduring significant discomfort. It's a reminder that our understanding of mental health is constantly evolving, and with continued research, we can find even more effective and compassionate treatments for those who need them most.
Date :
- Date Completed 2019-08-12
- Date Revised 2022-12-07
Further Info :
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