Paper Details
- Home
- Paper Details
Thrombin generation estimates the anticoagulation effect of direct oral anticoagulants with significant interindividual variability observed.
Author: HoPrahlad, NandurkarHarshal, NgCheryl, RiganoJoseph
Original Abstract of the Article :
: Direct oral anticoagulants (DOACs) are increasingly being used, primarily due to their drug stability and patient convenience. Although these drugs have been evaluated to be well tolerated in numerous clinical trials, their impact on in-vivo anticoagulation effect, variability and therapeutic drug...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1097/MBC.0000000000000678
データ提供：米国国立医学図書館（NLM）
Direct Oral Anticoagulants: A New Era in Thrombosis Management
Direct oral anticoagulants (DOACs) have revolutionized the treatment of thrombosis, offering greater convenience and efficacy compared to traditional anticoagulants. However, their impact on anticoagulation effect, variability, and therapeutic drug levels remains under investigation. This research examines the effect of DOACs on thrombin generation, a key process in blood clotting.
The authors investigated the effect of dabigatran, rivaroxaban, and apixaban on thrombin generation using a calibrated automated thrombogram. They found that each DOAC had a unique effect on thrombin generation, highlighting the importance of individual patient monitoring and personalized treatment strategies.
Understanding Variability: A Key to Personalized Medicine
This research highlights the significant interindividual variability in the anticoagulation effect of DOACs. It underscores the need for personalized medicine approaches to optimize treatment efficacy and minimize bleeding risk. This research emphasizes the importance of careful monitoring and individualized dosing strategies for patients on DOACs.
Staying Safe: Monitoring and Management
This research underscores the importance of regular monitoring and close collaboration with healthcare professionals for individuals taking DOACs. It emphasizes the need for individualized dosing strategies and careful monitoring to ensure optimal therapeutic benefit while minimizing bleeding risk. This research contributes to the growing body of knowledge about DOACs, paving the way for more personalized and effective anticoagulation therapy.
Dr.Camel's Conclusion
Just as a camel navigates the treacherous desert, managing anticoagulation with DOACs requires a keen understanding of individual variability and careful monitoring. This research emphasizes the importance of personalized medicine approaches to optimize treatment efficacy and ensure patient safety.
Date :
- Date Completed 2018-08-10
- Date Revised 2018-08-10
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.