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The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects.

Author: AzirakS, BilgicS, GuvencA N, KocamanN, OzerM K, Tastemir KorkmazD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver. Treatment with TQ significantly reduced weight gain induced by OLZ, increased total antioxidant status, and decreased oxidative stress, liver enzyme levels, and lipid levels.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Spr...See full text at original site
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引用元：
https://doi.org/10.4149/BLL_2017_119

データ提供：米国国立医学図書館（NLM）

Thymoquinone: A Potential Shield Against Olanzapine's Side Effects

The human body is a complex and delicate system, and the medications we use to treat various ailments can sometimes have unintended consequences. This study

explores the field of

pharmacology, examining the potential protective effects of thymoquinone, a compound found in black cumin seed, against the side effects of olanzapine, an antipsychotic medication. The researchers investigated the impact of thymoquinone on olanzapine-induced side effects in the liver and metabolic system of rats.

A New Approach to Mitigating Side Effects

The study found that thymoquinone significantly reduced the weight gain induced by olanzapine and improved various biochemical parameters, including total antioxidant status, high-density lipoprotein cholesterol, insulin levels, and markers of oxidative stress. Thymoquinone also significantly reduced the levels of liver enzymes, such as alanine aminotransferase, aspartate aminotransferase, and gamma glutamyl transpeptidase, suggesting a protective effect on liver function.

The Potential for Thymoquinone in Clinical Practice

This study provides promising evidence for the potential of thymoquinone as a protective agent against the side effects of olanzapine. The findings suggest that thymoquinone may offer a natural and safe approach to mitigating the negative consequences of this medication. Further research is needed to evaluate the efficacy and safety of thymoquinone in human clinical trials.

Dr. Camel's Conclusion

The desert of pharmacology is filled with hidden treasures, and thymoquinone appears to be a promising new discovery. This study suggests that thymoquinone may offer a natural and effective way to mitigate the side effects of olanzapine. While further research is needed, this study provides a glimmer of hope for individuals seeking to minimize the negative consequences of antipsychotic medication.

Date :
  1. Date Completed 2018-03-15
  2. Date Revised 2019-03-18
Further Info :

Pubmed ID

29198130

DOI: Digital Object Identifier

10.4149/BLL_2017_119

Related Literature

Article Analysis
・Side Effects of olanzapine
SNS
PICO Info
in preparation
Languages

English

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