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Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience.

Author: , BlancheStéphane, ClavelJacqueline, DollfusCatherine, FayeAlbert, GoujonStéphanie, HleyhelMira, MandelbrotLaurent, SibiudeJeanne, TubianaRoland, WarszawskiJosiane

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Overview

This study investigated the oncogenic risk of nucleoside analogues for treating HIV infection in uninfected children exposed in utero. While overall cancer incidence was not significantly different from that expected in the general population, didanosine exposure was associated with a significantly higher risk of cancer, particularly during the first trimester. This highlights the need for comprehensive evaluation of the transplacental genotoxicity of this antiretroviral class.
Paper Details　
Original Abstract of the Article :
All nucleoside analogues for treating HIV infection, due to their capacity to integrate into and alter human DNA, are experimentally genotoxic to some extent. The long-term oncogenic risk after in utero exposure remains to be determined. Cancer incidence in uninfected children exposed to nucleos(t)i...See full text at original site
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引用元：
https://doi.org/10.1002/em.22162

データ提供：米国国立医学図書館（NLM）

In Utero Exposure to Antiretroviral Nucleoside Analogues: A Comprehensive Analysis

This research investigates the potential long-term oncogenic risk associated with in utero exposure to antiretroviral nucleoside analogues, which are crucial for managing HIV infection. The authors analyzed data from a large cohort of children born to HIV-positive mothers in France, focusing on the incidence of cancer in those exposed to nucleoside reverse transcriptase inhibitors (NRTIs) during pregnancy. The researchers found an overall cancer incidence similar to that of the general population, but a significantly higher risk for children exposed to didanosine, particularly during the first trimester.

Didanosine and Cancer Risk: A Complex Interplay

The study highlights the importance of understanding the long-term effects of in utero exposure to antiretroviral medications. The findings suggest that didanosine might pose a specific oncogenic risk, particularly during early pregnancy. This research is like exploring a complex desert ecosystem, where even subtle changes in the environment can have significant long-term impacts.

Understanding the Risks: A Journey Towards Informed Decisions

The study provides valuable insights into the potential risks associated with in utero exposure to antiretroviral nucleoside analogues. The researchers' findings emphasize the need for further research to better understand the long-term health implications of these medications, particularly for pregnant women and their children.

Dr.Camel's Conclusion

This research highlights the importance of understanding the long-term health implications of in utero exposure to antiretroviral medications, particularly nucleoside reverse transcriptase inhibitors (NRTIs). The findings suggest that didanosine might pose a specific oncogenic risk, particularly during early pregnancy, emphasizing the need for further research and careful consideration of treatment options for pregnant women living with HIV.

Date :
  1. Date Completed 2019-12-12
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

29206312

DOI: Digital Object Identifier

10.1002/em.22162

Related Literature

Article Analysis
・Effects of didanosine
SNS
PICO Info
in preparation
Languages

English

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