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Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults.

Author: BloklandA, HeckmanP R A, LahuG, PrickaertsJ, SambethA, SmitS, TsaiM, UzT, Van DuinenM A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of roflumilast, a drug used to treat chronic obstructive pulmonary disease (COPD), on memory performance in humans. The study found that a low dose of roflumilast improved immediate recall performance and enhanced a brain wave associated with learning.
Paper Details　
Original Abstract of the Article :
The need for new and effective treatments for dementia remains indisputably high. Phosphodiesterase inhibitors (PDE-Is) have proven efficacy as cognitive enhancers based on their positive effects in numerous preclinical studies. Especially the PDE4 subfamily is of interest due to its expression in t...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuropharm.2017.12.019

データ提供：米国国立医学図書館（NLM）

Unlocking the Potential of Roflumilast for Memory Enhancement

This research delves into the intriguing world of [cognitive enhancers] and explores the potential of [roflumilast] to improve [verbal word memory]. The study employed a [double-blind, randomized, placebo-controlled, 4-way crossover design] to assess the effects of [roflumilast] on memory performance in healthy young adults. The researchers discovered that [acute administration of 100 μg roflumilast] significantly improved [immediate recall performance] and was accompanied by an enhanced [P600 peak] during word presentation.

A Glimpse into the Future of Memory Enhancement

The findings of this study provide a promising glimpse into the potential of [low-dose roflumilast administration] as a memory enhancer in humans. The researchers observed a [2-3 word increase in immediate recall performance] after [acute administration], suggesting that [roflumilast] may have a positive impact on memory function. This discovery could have significant implications for individuals seeking ways to improve their cognitive abilities.

Navigating the Brain's Desert of Memory

Just like a camel traversing the vast desert of memory, this research navigates the intricacies of the human mind. The discovery that [low-dose roflumilast administration] can enhance memory performance opens exciting possibilities for individuals seeking to improve their cognitive abilities. While more research is needed to fully understand the long-term implications, this study provides a compelling foundation for future investigations.

Dr.Camel's Conclusion

This research is like finding a hidden oasis of knowledge in the desert of memory. The discovery that [roflumilast] can enhance memory function is a promising development, potentially offering new pathways to improve cognitive abilities. However, like a wise camel, we must continue to explore and understand the nuances of the human mind before embarking on a grand journey of memory enhancement.

Date :
  1. Date Completed 2018-11-13
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

29241652

DOI: Digital Object Identifier

10.1016/j.neuropharm.2017.12.019

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・Side Effects of roflumilast
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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