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Mirabegron: potential off target effects and uses beyond the bladder.

Author: BengtssonTore, DehvariNodi, HutchinsonDana Sabine, da Silva JuniorEdilson Dantas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of mirabegron, a drug originally developed to treat overactive bladder, for other conditions, including heart failure and metabolic disease. Mirabegron is a beta-3 adrenoceptor agonist, a type of receptor that has been shown to improve metabolic function in animal studies.
Paper Details　
Original Abstract of the Article :
The &#946;<sub>3</sub> -adrenoceptor was initially an attractive target for several pharmaceutical companies due to its high expression in rodent adipose tissue, where its activation resulted in decreased adiposity and improved metabolic outputs (such as glucose handling) in animal models of obesity...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177610/

データ提供：米国国立医学図書館（NLM）

Mirabegron: Beyond the Bladder

The realm of drug development is a vast and often perplexing desert, with researchers constantly searching for new therapeutic targets. This study explores the potential of mirabegron, a β3-adrenoceptor agonist originally developed for obesity, to treat overactive bladder syndrome and potentially other conditions.

Mirabegron: A Multifaceted Oasis

The study highlights the intriguing off-target effects of mirabegron, suggesting it may have therapeutic potential beyond its current indication. The authors discuss the possibility of using mirabegron for heart failure and metabolic disease, demonstrating the potential for this drug to be a valuable resource in multiple areas of healthcare.

Exploring New Horizons

This research reminds us that the potential of a drug can extend beyond its initial intended use. It's like discovering a new oasis in the desert – unexpected opportunities can arise with careful exploration and research.

Dr.Camel's Conclusion

This research provides a glimpse into the exciting potential of mirabegron to address a range of health challenges. It's a reminder that we should always explore the desert of drug development with an open mind, ready to discover new and unexpected oases of therapeutic potential.

Date :
  1. Date Completed 2019-09-23
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29243229

DOI: Digital Object Identifier

PMC6177610

Related Literature

Article Analysis
・Effects of mirabegron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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