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Cellular electrophysiologic effects of dexamethasone sodium phosphate: implications for cardiac stimulation with steroid-eluting electrodes.

Author: BendittD G, DetloffB L, GornickC C, KriettJ M, RybergC, StokesK L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Dexamethasone impregnated pacemaker electrodes were associated with reduced energy requirements for stimulation. Acute exposure to dexamethasone was associated with some electrophysiologic effects, but chronic exposure had minimal impact on ventricular stimulation threshold.
Paper Details　
Original Abstract of the Article :
Impregnation of implantable cardiac pacemaker electrodes with dexamethasone sodium phosphate dexamethasone) has been associated with reduced energy requirements for both atrial and ventricular stimulation. To determine whether cardiac cellular electrophysiologic effects of dexamethasone could in par...See full text at original site
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引用元：
https://doi.org/10.1016/0167-5273(89)90137-x

データ提供：米国国立医学図書館（NLM）

Dexamethasone and Cardiac Stimulation: A Study of Electrophysiologic Effects

In the field of [cardiac pacing], the quest for [reducing energy requirements for stimulation] is a constant pursuit. This study investigates the [electrophysiologic effects of dexamethasone] on cardiac cells. The researchers used [microelectrode recording and stimulation techniques] to assess both the immediate and long-term effects of dexamethasone on isolated rabbit heart tissue. They found that [dexamethasone had a concentration-dependent effect on spontaneous atrial cycle length and a tendency to increase ventricular resting membrane potential]. These findings suggest that [dexamethasone may play a role in the reduced stimulation thresholds observed with dexamethasone-impregnated pacing electrodes].

Dexamethasone: A Potential Solution for Reduced Stimulation Thresholds

The researchers discovered that [acute exposure to dexamethasone resulted in a tendency to increase ventricular resting membrane potential and diminish stimulation threshold]. This finding is significant because it could explain why [dexamethasone-impregnated pacing electrodes require less energy for stimulation].

Understanding Dexamethasone's Influence on Cardiac Stimulation

These findings are important for understanding how dexamethasone affects the heart. The researchers observed [acute and chronic effects of dexamethasone on cardiac cells]. This knowledge is crucial for [optimizing the use of dexamethasone-impregnated pacing electrodes] and ensuring the safety and effectiveness of cardiac pacing procedures.

Dr.Camel's Conclusion

This study, like a camel navigating a sandy landscape, delves into the intricate workings of cardiac electrophysiology. The researchers provide valuable insights into how dexamethasone influences cardiac cells, paving the way for a deeper understanding of its potential applications in cardiac pacing. This research is a testament to the ongoing quest for better and more efficient ways to treat heart conditions.

Date :
  1. Date Completed 1989-04-27
  2. Date Revised 2019-08-16
Further Info :

Pubmed ID

2925287

DOI: Digital Object Identifier

10.1016/0167-5273(89)90137-x

Related Literature

Article Analysis
・Effects of sodium phosphate
SNS
PICO Info
in preparation
Languages

English

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