Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria.

Author: AdachiSoichiro, AzumaTakeshi, FukudaShinji, HoshiNamiko, InoueJun, IshidaTsukasa, KongLingling, KuYuna, OoiMakoto, OtsukaTakafumi, TsukimiTomoya, WatanabeDaisuke, YamairiHaruka, YasutomiEiichiro, YoshidaMasaru

Paper Details 
Original Abstract of the Article :
Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in th...See full text at original site
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引用元:
https://doi.org/10.1007/s10620-017-4905-3

データ提供:米国国立医学図書館(NLM)

Proton Pump Inhibitors: Opening the Door to Enteropathogens

The world of our gut microbiome is a complex and delicate ecosystem, like a delicate desert oasis. This research, like a careful scientist, investigates the impact of proton pump inhibitors (PPIs), a common medication, on the susceptibility to oral infection by enteropathogens. The researchers explored how PPIs, specifically lansoprazole, might affect the balance of this ecosystem, potentially creating vulnerabilities for invading pathogens.

PPIs: A Gateway for Enteropathogens

The study revealed that lansoprazole, a commonly used PPI, can increase susceptibility to oral infection by enteropathogens in mice. This finding suggests that PPIs might disrupt the delicate balance of the gut microbiome, making it more vulnerable to bacterial invaders. This is like opening a gate in the desert oasis, allowing opportunistic pathogens to enter and disrupt the delicate ecosystem.

Protecting Our Desert Oasis: A Guide for Patients

This research highlights the potential impact of PPIs on the gut microbiome. This study reminds us that even common medications can have unexpected consequences for our health. It's like reminding us to be careful not to disturb the delicate balance of our desert oasis, ensuring its continued health and well-being.

Dr. Camel's Conclusion

This research sheds light on the potential impact of PPIs on the gut microbiome, suggesting that these medications might create vulnerabilities for enteropathogenic infections. This study is like a warning sign in the desert, reminding us to be mindful of the potential consequences of our medication choices and the importance of maintaining a healthy gut microbiome.

Date :
  1. Date Completed 2018-05-22
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

29327263

DOI: Digital Object Identifier

10.1007/s10620-017-4905-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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