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Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria.
Author: AdachiSoichiro, AzumaTakeshi, FukudaShinji, HoshiNamiko, InoueJun, IshidaTsukasa, KongLingling, KuYuna, OoiMakoto, OtsukaTakafumi, TsukimiTomoya, WatanabeDaisuke, YamairiHaruka, YasutomiEiichiro, YoshidaMasaru
Original Abstract of the Article :
Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s10620-017-4905-3
データ提供:米国国立医学図書館(NLM)
Proton Pump Inhibitors: Opening the Door to Enteropathogens
The world of our gut microbiome is a complex and delicate ecosystem, like a delicate desert oasis. This research, like a careful scientist, investigates the impact of proton pump inhibitors (PPIs), a common medication, on the susceptibility to oral infection by enteropathogens. The researchers explored how PPIs, specifically lansoprazole, might affect the balance of this ecosystem, potentially creating vulnerabilities for invading pathogens.
PPIs: A Gateway for Enteropathogens
The study revealed that lansoprazole, a commonly used PPI, can increase susceptibility to oral infection by enteropathogens in mice. This finding suggests that PPIs might disrupt the delicate balance of the gut microbiome, making it more vulnerable to bacterial invaders. This is like opening a gate in the desert oasis, allowing opportunistic pathogens to enter and disrupt the delicate ecosystem.
Protecting Our Desert Oasis: A Guide for Patients
This research highlights the potential impact of PPIs on the gut microbiome. This study reminds us that even common medications can have unexpected consequences for our health. It's like reminding us to be careful not to disturb the delicate balance of our desert oasis, ensuring its continued health and well-being.
Dr. Camel's Conclusion
This research sheds light on the potential impact of PPIs on the gut microbiome, suggesting that these medications might create vulnerabilities for enteropathogenic infections. This study is like a warning sign in the desert, reminding us to be mindful of the potential consequences of our medication choices and the importance of maintaining a healthy gut microbiome.
Date :
- Date Completed 2018-05-22
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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