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Clinical and metabolic effects associated with weight changes and obeticholic acid in non-alcoholic steatohepatitis.

Author: , ChalasaniN, GillR M, HameedB, HoofnagleJ H, LoombaR, TerraultN A, Van NattaM L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Obeticholic acid (OCA) leads to weight loss in patients with non-alcoholic steatohepatitis (NASH), and OCA therapy and weight loss have additive benefits on serum aminotransferases and histology.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In a 72-week, randomised controlled trial of obeticholic acid (OCA) in non-alcoholic steatohepatitis (NASH), OCA was superior to placebo in improving serum ALT levels and liver histology. OCA therapy also reduced weight. AIMS: Because weight loss by itself can improve histology, to perf...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29333665

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid: A Desert Oasis for Non-Alcoholic Steatohepatitis?

The world of liver health is a challenging desert, with scientists constantly searching for effective treatments for non-alcoholic steatohepatitis (NASH). This study examines the impact of obeticholic acid (OCA) on NASH, focusing on its effects on weight loss and liver health. The researchers analyzed data from a 72-week randomized controlled trial, evaluating the effectiveness of OCA in comparison to placebo. The study findings suggest that OCA may offer a promising approach to managing NASH, particularly in those who experience weight loss. This research is like finding a hidden oasis in the desert, providing a potential source of relief for individuals battling NASH.

Navigating the Desert of NASH

The study's findings highlight the potential benefits of OCA for NASH patients, especially those who experience weight loss. It demonstrates a positive impact on serum ALT levels, liver histology, and overall NASH activity. Think of OCA as a resourceful camel, able to navigate the treacherous desert of NASH and deliver valuable benefits to those in need. The researchers' meticulous analysis provides valuable insights into the potential of OCA in managing this complex liver disease.

A Balancing Act in NASH Management

While the study showcases the potential benefits of OCA for NASH patients, it also underscores the importance of managing its metabolic effects. The researchers observed both positive and negative changes in lipid profiles and blood glucose levels with OCA treatment, highlighting the need for careful monitoring and individualized treatment plans. This research is like a seasoned camel herder, navigating the complex landscape of NASH management, carefully considering the needs of each individual.

Dr.Camel's Conclusion

This research provides valuable insights into the potential of OCA in managing NASH, particularly in those who experience weight loss. However, it is essential to carefully monitor metabolic effects and develop individualized treatment plans to ensure optimal patient outcomes. The study's findings, like a compass in the desert, guide us towards a better understanding of NASH and its management.

Date :
  1. Date Completed 2019-03-12
  2. Date Revised 2020-04-14
Further Info :

Pubmed ID

29333665

DOI: Digital Object Identifier

NIHMS958481

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・Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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