Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.

Author: , AlmeidaIgor C, Alonso-VegaCristina, AlvesFabiana, GasconJoaquim, OrtizLourdes, PinazoMaría-Jesús, RibeiroIsabela, SchijmanAlejandro, Strub-WourgaftNathalie, TorricoFaustino

Paper Details 
Original Abstract of the Article :
BACKGROUND: Chagas disease is a major neglected vector-borne disease. In this study, we investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole prodrug) regimens and benznidazole versus placebo in adult chronic indeterminate Chagas disease. METHOD: In this proof-of-co...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/29352704

データ提供:米国国立医学図書館(NLM)

Treating Chronic Indeterminate Chagas Disease: Exploring New Treatment Regimens

Chagas disease is a neglected tropical disease that affects millions worldwide. This study explores the efficacy and safety of different treatment regimens for chronic indeterminate Chagas disease, a stage of the disease where the parasite remains dormant but can reactivate later in life. The research investigates the potential of benznidazole, a standard treatment, and three different dosing regimens of E1224, a novel antifungal drug, in treating this form of Chagas disease. The study provides valuable insights into the potential for new treatment options and the importance of continued research to develop more effective and safer therapies for Chagas disease.

New Treatment Regimens for Chagas Disease: A Step Towards a Cure

The study demonstrates the potential of E1224 as a new treatment option for Chagas disease. While the study shows that benznidazole remains a highly effective treatment, the findings suggest that E1224, particularly at higher doses, may also offer a valuable therapeutic option, potentially opening new avenues for treatment and management of this neglected tropical disease. It's like discovering a new oasis in the desert of Chagas disease research, offering hope for a more effective and accessible treatment.

Navigating the Desert of Chagas Disease: Seeking Effective Treatment

This research highlights the ongoing efforts to develop more effective and safer treatments for Chagas disease. The study's findings encourage further research and development of new therapies to combat this debilitating disease. It's like navigating a vast desert, where the challenges are numerous but the potential for discovery and progress remains strong. The study underscores the importance of collaboration and innovation in tackling this global health challenge.

Dr.Camel's Conclusion

The study demonstrates the potential of E1224 as a new treatment option for Chagas disease, alongside the proven efficacy of benznidazole. It's like discovering a new oasis in the desert of Chagas disease research, offering hope for a more effective and accessible treatment. The research underscores the importance of collaboration and innovation in tackling this global health challenge. It's like navigating a vast desert, where the challenges are numerous but the potential for discovery and progress remains strong.

Date :
  1. Date Completed 2019-02-25
  2. Date Revised 2022-04-05
Further Info :

Pubmed ID

29352704

DOI: Digital Object Identifier

EMS140849

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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