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Success of rechallenging dabrafenib and trametinib combination therapy after trametinib-induced rhabdomyolysis: a case report.

Author: MutoYusuke, NamikawaKenjiro, NgWilliam, NishidaMakiko, TakahashiAkira, TsutsumidaArata, YamazakiNaoya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

A combination therapy of dabrafenib and trametinib was effective for BRAF-mutant advanced melanomas, but a rare adverse event of rhabdomyolysis was reported.
Paper Details　
Original Abstract of the Article :
The mitogen-activated protein kinase pathway regulates cell growth and differentiation and is activated by BRAF mutations. BRAF mutations are present in about 40-50% of cutaneous melanomas. More than 90% of BRAF mutations are the V600E type. BRAF inhibitor (dabrafenib or vemurafenib) and MEK inhibit...See full text at original site
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引用元：
https://doi.org/10.1097/CMR.0000000000000424

データ提供：米国国立医学図書館（NLM）

Dabrafenib and Trametinib: A Camel's Tale of Resilience in Cancer Treatment

Cancer treatment, my friends, is a delicate balancing act. It's like navigating a treacherous desert with a precious cargo. This case report tells a story of resilience, of a patient battling melanoma who faced a serious side effect from her cancer treatment. The patient, after experiencing rhabdomyolysis (muscle breakdown) caused by the drug trametinib, was able to successfully resume the treatment combination of dabrafenib and trametinib. This is a rare case and offers hope for other patients facing similar challenges. The report highlights the importance of careful monitoring and individualized treatment approaches in cancer care.

A Camel's Tale of Resilience in Cancer Treatment: Rechallenging Dabrafenib and Trametinib

This report shows that it may be possible to safely reintroduce dabrafenib and trametinib combination therapy in some patients who have experienced trametinib-induced rhabdomyolysis. This information could offer hope for other patients facing similar challenges.

A Camel's Tale of Resilience in Cancer Treatment: Implications for Cancer Care

This case report underscores the need for careful monitoring and individualized treatment approaches in cancer care. It reminds us that while side effects can be challenging, they don't always mean the end of effective treatment. It also emphasizes the importance of continued research to better understand the nuances of drug combinations and their impact on individual patients.

Dr.Camel's Conclusion

This case report highlights the potential for successful rechallenging of dabrafenib and trametinib combination therapy in patients who have experienced trametinib-induced rhabdomyolysis, emphasizing the importance of careful monitoring and individualized treatment approaches in cancer care. This research provides a beacon of hope for other patients facing similar challenges and underscores the need for continued research to understand the complexities of drug combinations and their impact on individual patients.

Date :
  1. Date Completed 2019-02-01
  2. Date Revised 2019-02-01
Further Info :

Pubmed ID

29356791

DOI: Digital Object Identifier

10.1097/CMR.0000000000000424

SNS
PICO Info
in preparation
Languages

English

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