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A novel in-cell ELISA method for screening of compounds inhibiting TRKA phosphorylation, using KM12 cell line harboring TRKA rearrangement.

Author: MitraSayan, PandreManoj Kumar, Satya PratapVeera Venkata Valluri, ShaikShama, YadlapalliPrasad, YanamandraMahesh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A novel in-cell ELISA method was developed to quantify the phosphorylation of TRK kinase in cells harboring TRK fusion proteins.
Paper Details　
Original Abstract of the Article :
Tropomyosin-related kinase A (TRKA) fusion was originally detected in colorectal carcinoma that had resulted in expression of the oncogenic chimeric protein TPM3-TRKA. Lately, many more rearrangements in TRK family of kinases generating oncogenic fusion proteins have been identified. These genetic r...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1016/j.ab.2018.01.014

データ提供：米国国立医学図書館（NLM）

A Novel Method for Screening TRKA Inhibitors: A New Tool for Cancer Research

Cancer research is a vast and complex desert, requiring innovative approaches to identify new treatments. This study focuses on developing a novel in-cell ELISA method for screening compounds that inhibit TRKA phosphorylation, a key process in the development of certain cancers. The researchers aimed to create a more efficient and cost-effective method for identifying potential drug candidates.

A More Efficient Way to Screen Drug Candidates

The study successfully developed a robust and versatile in-cell ELISA method for screening TRKA inhibitors. This new method is more efficient and cost-effective than traditional methods, making it an important tool for researchers seeking to develop new cancer treatments. The study's findings highlight the power of innovation in the field of cancer research, paving the way for more efficient drug discovery and development.

Harnessing the Power of Innovation in Cancer Research

This research is like a wellspring of hope in the desert of cancer research, providing researchers with a new tool for identifying potential drug candidates. The study's findings underscore the importance of ongoing innovation in the quest for effective cancer treatments. This research serves as a beacon of hope for future progress in the fight against cancer.

Dr.Camel's Conclusion

This study, like a resourceful desert explorer discovering a new oasis, presents a valuable contribution to the field of cancer research. The new in-cell ELISA method promises to accelerate the discovery of effective treatments, offering a glimmer of hope in the fight against this devastating disease.

Date :
  1. Date Completed 2018-12-24
  2. Date Revised 2020-11-16
Further Info :

Pubmed ID

29360440

DOI: Digital Object Identifier

10.1016/j.ab.2018.01.014

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English

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