Comparative pharmacology and toxicology of tramadol and tapentadol.

Author: BarbosaJ, CarvalhoF, Dinis-OliveiraR J, FariaJ, MoreiraR, QueirósO

Paper Details 
Original Abstract of the Article :
Moderate-to-severe pain represents a heavy burden in patients' quality of life, and ultimately in the society and in healthcare costs. The aim of this review was to summarize data on tramadol and tapentadol adverse effects, toxicity, potential advantages and limitations according to the context of c...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1002/ejp.1196

データ提供:米国国立医学図書館(NLM)

Comparative Pharmacology and Toxicology of Tramadol and Tapentadol

This study explores the vast and complex landscape of pain management, focusing on the two commonly prescribed medications, tramadol and tapentadol. The study uses a comprehensive literature review, meticulously examining existing research on the pharmacological and toxicological profiles of these drugs. The key findings highlight the potential advantages of tapentadol over tramadol, particularly in terms of its lower serotonergic activity, dependence and abuse potential, and greater gastrointestinal tolerability. These findings provide valuable insights for clinicians seeking to optimize pain management for their patients.

Tapentadol: A Potential Advantage in Pain Management

The study suggests that tapentadol may offer a more favorable profile compared to tramadol in pain management, with potentially lower risks of serotonergic effects, dependence, and abuse. This is significant for clinicians and patients seeking to balance pain relief with minimizing the potential for adverse effects and addiction. While further research is needed to definitively establish the optimal opioid for individual patients, tapentadol shows promising potential as a safe and effective pain management option.

Navigating the Desert of Pain Management

This study offers valuable guidance for navigating the complex desert of pain management. It highlights the importance of carefully considering the individual patient's needs and risk factors when selecting an opioid, emphasizing the potential benefits and limitations of different medications. The study reminds us that the search for effective and safe pain management solutions is an ongoing journey, requiring ongoing research and careful consideration of individual patient needs.

Dr.Camel's Conclusion

This study is like a compass in the vast and sometimes treacherous desert of pain management, providing clinicians with valuable insights into the pharmacological and toxicological profiles of two commonly prescribed opioids. The findings suggest that tapentadol may offer a more favorable profile compared to tramadol, potentially reducing risks of serotonergic effects, dependence, and abuse. However, the study emphasizes the importance of individualized treatment plans, acknowledging that the choice of opioid should be tailored to the specific patient's needs and risk factors. Just as a desert traveler must carefully choose their path, clinicians must carefully select the most appropriate medication for each patient to ensure safe and effective pain management.

Date :
  1. Date Completed 2019-01-10
  2. Date Revised 2019-01-10
Further Info :

Pubmed ID

29369473

DOI: Digital Object Identifier

10.1002/ejp.1196

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.