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Efficacy and safety profile of paliperidone palmitate injections in the management of patients with schizophrenia: an evidence-based review.

Author: EmsleyRobin, KilianSanja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Paliperidone palmitate (PP) is a long-acting injectable antipsychotic medication used to treat schizophrenia. Studies show that PP is effective compared to placebo and comparable to other antipsychotics like risperidone. PP is generally well-tolerated but can cause side effects such as prolactin elevation, weight gain, and extrapyramidal symptoms. PP offers advantages like a large research database, various formulations, and rapid onset of action without oral antipsychotic supplementation.
Paper Details　
Original Abstract of the Article :
The course of schizophrenia is characterized by multiple relapses, incomplete remission of symptoms, enduring cognitive deficits, and social and occupational functional impairments. Nonadherence to antipsychotic medication is a major determinant of this poor outcome. Long-acting injectable antipsych...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759847/

データ提供：米国国立医学図書館（NLM）

Paliperidone Palmitate: A Long-Acting Solution for Schizophrenia

Schizophrenia is a complex and challenging mental illness, a journey through a desert of distorted thoughts and emotions. Treatment often involves antipsychotic medication, but ensuring adherence to a medication regimen can be difficult. This review examines the use of paliperidone palmitate, a long-acting injectable formulation of paliperidone, for the management of schizophrenia.

Long-Acting Injectables: A Path Towards Consistency

Long-acting injectable antipsychotics offer a solution to the problem of medication nonadherence. Paliperidone palmitate is a long-acting injectable antipsychotic that provides sustained medication levels, reducing the need for frequent oral doses. Think of it as a camel caravan carrying a supply of water that will last for the entire journey, ensuring that the camels stay hydrated even in the harsh desert environment.

Paliperidone Palmitate: A Promising Option

This review summarizes the evidence for the efficacy and safety of paliperidone palmitate in treating schizophrenia. Studies have shown that paliperidone palmitate is effective in reducing symptoms and improving patient outcomes. The availability of different formulations, including once-monthly and three-monthly injections, provides flexibility and convenience for patients. This is like having multiple options for crossing the desert, choosing the route that best suits the needs of the caravan.

Dr.Camel's Conclusion

This review highlights the potential of paliperidone palmitate as an effective and convenient treatment option for schizophrenia. Long-acting injectables can help address the challenges of medication nonadherence, leading to improved outcomes for patients. This research is like finding a new and reliable source of water in the desert, a solution that can help sustain individuals on their journey toward recovery.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

29379293

DOI: Digital Object Identifier

PMC5759847

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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