Antileukemic effects of neurokinin-1 receptor inhibition on hematologic malignant cells: a novel therapeutic potential for aprepitant.

Author: BashashDavood, BayatiSamaneh, GhaffariSeyed H, RazaniElham, SafaMajid, Safaroghli-AzarAva

Paper Details 
Original Abstract of the Article :
Genetic and laboratory studies have remodeled the conventional understanding of cancer pathogenesis by identifying different molecular alterations. Intrigued by the contribution of neurokinin-1 receptor (NK1R) network in cancer pathogenesis, we investigated the antileukemic effects of aprepitant, a ...See full text at original site
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引用元:
https://doi.org/10.1097/CAD.0000000000000591

データ提供:米国国立医学図書館(NLM)

A New Approach to Leukemia Treatment: Targeting the Neurokinin-1 Receptor

Cancer research is a vast and complex desert, with researchers constantly searching for new oases of hope. This study takes a unique approach, exploring the potential of aprepitant, a medication typically used to prevent nausea, as a novel treatment for leukemia. The study focuses on the neurokinin-1 receptor (NK1R), a molecular pathway that plays a role in cancer development, and investigates the antileukemic effects of aprepitant, a nonpeptide antagonist of NK1R. The researchers discovered that aprepitant demonstrated antileukemic activity by interfering with the cell cycle, promoting apoptosis, and even enhancing the effectiveness of other chemotherapy drugs.

Aprepitant: A Multifaceted Weapon Against Leukemia

The study found that aprepitant exhibited broad antileukemic effects, impacting multiple cellular processes. This multifaceted approach, like a camel with multiple pouches for carrying supplies, provides a promising new direction for leukemia treatment.

A New Oasis in the Cancer Landscape

This research suggests a promising new avenue for treating leukemia, potentially leading to better outcomes for patients. While more research is needed to fully understand the potential of aprepitant in this context, this study provides a valuable roadmap for future explorations. It's like discovering a new oasis in the desert, a place where hope for recovery can flourish.

Dr. Camel's Conclusion

The study demonstrates the potential of targeting the neurokinin-1 receptor with aprepitant as a novel strategy for treating leukemia. This innovative approach holds promise for enhancing existing therapies and offers new hope for patients battling this devastating disease. The findings are a testament to the ongoing quest for new solutions in the fight against cancer, a journey that continues to uncover exciting new pathways in the vast desert of scientific discovery.

Date :
  1. Date Completed 2018-05-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29389803

DOI: Digital Object Identifier

10.1097/CAD.0000000000000591

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Languages

English

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