Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress.

Author: AkaiRyoko, FujiwaraChisako, IshikawaOsamu, IwawakiTakao, MotegiSei-Ichiro, NakamuraHideharu, OginoSachiko, PereraBuddhini, SekiguchiAkiko, UchiyamaAkihiko, UeharaAkihito, YamazakiSahori, YokoyamaYoko

Paper Details 
Original Abstract of the Article :
We previously identified that botulinum toxin A (BTX-A) suppressed pressure ulcer (PU) formation after cutaneous ischemia-reperfusion (I/R) injury; however, regulation of cutaneous I/R-induced oxidative and endoplasmic reticulum (ER) stress by BTX-B was not investigated. Additionally, the efficacy o...See full text at original site
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引用元:
https://doi.org/10.1016/j.jdermsci.2018.01.006

データ提供:米国国立医学図書館(NLM)

Botulinum Toxin B: A Potential Oasis in the Desert of Pressure Ulcer Prevention

This study examines the potential of botulinum toxin B (BTX-B) in preventing pressure ulcer (PU) formation in a mouse model of cutaneous ischemia-reperfusion (I/R) injury. The research explores the effects of BTX-B on oxidative stress and endoplasmic reticulum (ER) stress, two key factors involved in PU development. The authors aim to determine whether BTX-B can effectively suppress PU formation by mitigating these cellular stress responses.

Botulinum Toxin B: A Promising New Dune in the Landscape of Pressure Ulcer Prevention

This study offers a glimmer of hope in the desert of pressure ulcer prevention research. The research suggests that BTX-B may be an effective tool in preventing PU formation by mitigating oxidative and ER stress. The findings are particularly encouraging, highlighting the potential of BTX-B as a novel therapeutic approach to address this challenging clinical problem.

Pressure Ulcers: Navigating the Shifting Sands of Prevention and Treatment

This study underscores the importance of preventing pressure ulcers, a significant health concern, particularly for individuals with limited mobility. The research highlights the potential of BTX-B as a promising new tool in this field. While further research is needed to confirm these findings and explore the optimal dosage and application methods, the study offers a valuable starting point for developing new therapeutic strategies.

Dr. Camel's Conclusion

This study is a welcome addition to the growing body of knowledge on pressure ulcer prevention. Botulinum toxin B emerges as a promising new tool in the fight against this challenging condition. The research encourages further exploration of BTX-B and its potential applications in clinical practice, paving the way for more effective and innovative approaches to pressure ulcer prevention and treatment.

Date :
  1. Date Completed 2018-09-20
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

29402605

DOI: Digital Object Identifier

10.1016/j.jdermsci.2018.01.006

Related Literature

SNS
PICO Info
in preparation
Languages

English

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