Paper Details

  1. Home
  2. Paper Details

Suramin-Induced Neurotoxicity: Preclinical Models and Neuroprotective Strategies.

Author: BalkayaMustafa, BoehmerleWolfgang, EndresMatthias, HuehnchenPetra, PeruzzaroSarah, von der AheDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Suramin, a trypan blue analogon, was found to induce neurotoxic effects on dorsal root ganglia neurons (DRGN) in vitro. The neurotoxic effects were associated with a suramin-induced Ca<sup>2+</sup> influx into DRGN. Co-incubation of suramin and the VGCC inhibitor nimodipine partially improved cell viability.
Paper Details　
Original Abstract of the Article :
Suramin is a trypan blue analogon originally developed to treat protozoan infections, which was found to have diverse antitumor effects. One of the most severe side effects in clinical trials was the development of a peripheral sensory-motor polyneuropathy. In this study, we aimed to investigate sur...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017835/

データ提供：米国国立医学図書館（NLM）

Suramin-Induced Neurotoxicity: Exploring the Mechanism and Protective Strategies

We're venturing into the realm of neuropharmacology, exploring the potential neurotoxic effects of suramin, a drug with antitumor properties. This study investigates the mechanism of suramin-induced neuropathy, focusing on calcium homeostasis as a potential pathomechanism. The research sheds light on the underlying mechanisms of suramin-induced neurotoxicity and explores potential neuroprotective strategies.

Understanding and Mitigating Suramin-Induced Neurotoxicity

This study provides valuable insights into the mechanism of suramin-induced neurotoxicity, highlighting the role of calcium dyshomeostasis in the development of peripheral sensory-motor polyneuropathy. The research also explores the potential of calcium channel blockers, such as nimodipine, as neuroprotective agents. The results, like a cool spring in the middle of a desert, offer a promising avenue for mitigating the neurotoxic effects of suramin.

Suramin and Neurotoxicity

Suramin, a drug used to treat protozoan infections, has been found to have antitumor effects. However, it can also cause neurotoxicity, leading to peripheral neuropathy. This study sheds light on the mechanism of this neurotoxicity, paving the way for developing strategies to mitigate these adverse effects.

Dr.Camel's Conclusion

This research, like a map guiding us through the intricate landscape of neurotoxicity, offers important insights into the mechanism of suramin-induced neuropathy. This study paves the way for exploring novel strategies to mitigate the neurotoxic effects of suramin, ensuring that its therapeutic benefits can be harnessed safely and effectively.

Date :
  1. Date Completed 2018-08-14
  2. Date Revised 2018-12-07
Further Info :

Pubmed ID

29414872

DOI: Digital Object Identifier

PMC6017835

Related Literature

Article Analysis
・Side Effects of nimodipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.