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Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth).

Author: ForbesBen, GarciaCristina M Aller, MalallahOsamah S, ProctorGordon B, RoyallPaul G

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review examines the technologies for the local delivery of saliva-stimulating agents, including oral disintegrating tablets, oral disintegrating films, medicated chewing gums, and implantable drug delivery devices.
Paper Details　
Original Abstract of the Article :
Radiotherapy is a life-saving treatment for head and neck cancers, but almost 100% of patients develop dry mouth (xerostomia) because of radiation-induced damage to their salivary glands. Patients with xerostomia suffer symptoms that severely affect their health as well as physical, social and emoti...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2018.02.004

データ提供：米国国立医学図書館（NLM）

Buccal Drug Delivery: A New Approach for Xerostomia

Xerostomia, or dry mouth, is a debilitating side effect of radiotherapy for head and neck cancers. This research explores the potential of buccal drug delivery technologies for treating radiation-induced xerostomia, aiming to provide patients with a more effective and patient-friendly treatment option.

Rethinking Xerostomia Treatment

The study suggests that buccal drug delivery technologies, such as oral disintegrating tablets (ODTs), oral disintegrating films, and medicated chewing gums, offer a promising approach for treating xerostomia. These technologies allow for localized drug delivery, directly targeting the buccal mucosa and activating the minor salivary glands, while minimizing systemic side effects.

A More Comfortable and Effective Treatment

This research highlights the need for patient-centered treatment approaches for xerostomia. Buccal drug delivery technologies offer a more convenient and effective option compared to traditional treatment methods. This research is like discovering a new oasis in the desert of xerostomia treatment, providing a refreshing and effective solution for patients suffering from this debilitating condition.

Dr.Camel's Conclusion

Xerostomia is like a persistent desert wind, drying out the mouth and causing discomfort. This research, like a caravan carrying precious water, offers a new approach to delivering medication directly to the affected area. This innovation could help patients navigate the challenges of xerostomia more comfortably, leading to a more pleasant journey.

Date :
  1. Date Completed 2018-09-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29425763

DOI: Digital Object Identifier

10.1016/j.ijpharm.2018.02.004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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