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Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex.

Author: AlvingCarl R, BeckZoltan, LanarDavid E, MatyasGary R, TorresOscar B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Adding Army Liposome Formulation (ALF) to aluminum salt-adsorbed antigens significantly increased the immune potency of the antigens. ALFA induced a Th2-type response, while ALFQ and ALFQA induced more balanced Th1/Th2 responses. This finding suggests potential for enhancing vaccine efficacy.
Paper Details　
Original Abstract of the Article :
Aluminum salts have been used as vaccine adjuvants for >50 years, and they are currently present in at least 146 licensed vaccines worldwide. In this study we examined whether adsorption of Army Liposome Formulation (ALF) to an aluminum salt that already has an antigen adsorbed to it might result in...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29432824

データ提供：米国国立医学図書館（NLM）

Boosting Immune Response: Co-adsorption of Adjuvants to Aluminum Hydroxide

This study delves into the world of vaccine adjuvants, exploring the potential of co-adsorbing different adjuvants to aluminum hydroxide (AH) to enhance immune responses. The study investigated the effects of co-adsorbing Army Liposome Formulation (ALF) or ALFQ adjuvant to the aluminum-antigen complex, finding that this approach significantly increased the immune potency of the antigen adsorbed to AH. The study provides valuable insights into the potential of combining different adjuvants to optimize vaccine efficacy and tailor immune responses to specific antigens.

Adjuvants: A Symphony of Immune Stimulation

This study demonstrates the potential of combining adjuvants to amplify immune responses. The research shows that co-adsorbing ALF or ALFQ to aluminum hydroxide significantly enhances the immune potency of antigens, suggesting that this approach could lead to more effective vaccines. This symphony of immune stimulation highlights the intricate interplay of different adjuvants in shaping immune responses, offering exciting possibilities for vaccine development and optimization.

The Desert of Immune Responses

This research explores the intricate landscape of immune responses and the potential of adjuvants to modulate these responses. The study's findings offer valuable insights into the potential of combining different adjuvants to enhance vaccine efficacy. The researchers have embarked on a journey across the vast desert of immune responses, seeking new ways to optimize vaccine effectiveness and conquer infectious diseases.

Dr. Camel's Conclusion

This research explores the intricate world of adjuvants, demonstrating that combining different adjuvants can amplify immune responses. The study's findings offer valuable insights into the potential of co-adsorbing adjuvants to aluminum hydroxide, suggesting that this approach could lead to more effective vaccines. This research serves as a reminder that we are constantly exploring new frontiers in vaccine development, seeking innovative ways to harness the power of our immune system to protect against infectious diseases.

Date :
  1. Date Completed 2019-05-02
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29432824

DOI: Digital Object Identifier

NIHMS943868

Related Literature

Article Analysis
・Effects of aluminum hydroxide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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