Paper Details

  1. Home
  2. Paper Details

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye.

Author: AgelidisAlex, AmesJoshua, HadigalSatvik, JaishankarDinesh, ShuklaDeepak, ThakkarNeel, YadavalliTejabhiram, YakoubAbraam M

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

BX795, a TBK1 inhibitor, demonstrated strong antiviral activity against HSV-1 in various models, including cultured cells, animal corneas, and a murine model of ocular infection. BX795 targets Akt phosphorylation in infected cells, leading to the blockage of viral protein synthesis. This inhibitor, effective against both sensitive and ACV-resistant HSV-1 strains, presents a promising alternative for treating ocular herpes infection.
Paper Details　
Original Abstract of the Article :
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) form the primary class of antiherpetic drugs, but this class suffers limitations due to the emergence of viral resistance and...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/29444978

データ提供：米国国立医学図書館（NLM）

A New Frontier in Herpes Treatment: Off-Target Effects to the Rescue

Herpes simplex virus type 1 (HSV-1), a persistent virus that can cause recurring eye infections, is a troublesome desert nomad, often returning to cause discomfort. This study explores the potential of BX795, a drug initially designed for another purpose, to combat HSV-1 infections. The researchers discovered that BX795 has an unexpected, but beneficial, effect on the virus, like finding a hidden oasis that provides protection from the nomad's attacks.

The Unexpected Power of BX795

The researchers found that BX795 can effectively inhibit HSV-1 infection in the eye, even against strains that are resistant to traditional treatments. It's like discovering a new weapon in the arsenal against this persistent desert nomad, offering a fresh approach to combat the infection.

Hope for Eye Infections: A New Perspective

This research provides a glimmer of hope for individuals struggling with HSV-1 eye infections, offering a potential new weapon to fight this persistent foe. It's like finding a way to seal off the desert oasis from the nomad's attacks, offering a path towards relief and recovery.

Dr.Camel's Conclusion

This research is a testament to the power of serendipity in science. It's like finding a hidden oasis while searching for a different destination. The researchers stumbled upon a valuable new treatment option for HSV-1 eye infections, reminding us that innovation can often emerge from unexpected sources. This research represents a significant step forward in the fight against this persistent virus, offering a new path towards healthier eyes and a brighter future.

Date :
  1. Date Completed 2019-09-16
  2. Date Revised 2020-10-09
Further Info :

Pubmed ID

29444978

DOI: Digital Object Identifier

NIHMS1629274

Related Literature

Article Analysis
・Side Effects of acyclovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.