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Glutamatergic Modulators in Depression.

Author: HenterIoline D, ZarateCarlos A, de SousaRafael Teixeira

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This article highlights the evidence supporting the antidepressant effects of various glutamatergic modulators, including ketamine, esketamine, dextromethorphan, dextromethorphan-quinidine, AVP-786, nitrous oxide, AZD6765, CP-101,606/traxoprodil, MK-0657, D-cycloserine, GLYX-13, sarcosine, AV-101, AZD2066, RO4917523/basimglurant, JNJ40411813/ADX71149, and R04995819.
Paper Details　
Original Abstract of the Article :
After participating in this activity, learners should be better able to evaluate the evidence supporting the antidepressant effects of glutamatergic modulators.Both preclinical and clinical studies have implicated glutamatergic system dysfunction in the pathophysiology of mood disorders such as bipo...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29465478

データ提供：米国国立医学図書館（NLM）

Glutamatergic Modulators: A New Oasis in the Desert of Depression

This study explores the role of glutamatergic system dysfunction in the pathophysiology of mood disorders, specifically bipolar depression and major depressive disorder. The research highlights the potential of glutamatergic modulators, particularly ketamine, as a promising treatment option for depression. The study also explores the potential of other glutamatergic modulators, both as monotherapy and as adjunctive therapies.

Finding the Right Path: The Promise of Glutamatergic Modulators

Depression can be a challenging and debilitating condition, often resistant to traditional treatments. This study delves into the potential of glutamatergic modulators, offering a new avenue for treating depression. The research highlights the rapid antidepressant effects observed with ketamine, providing a glimmer of hope for those struggling with this complex condition. The study's findings suggest that further research into glutamatergic modulators could lead to the development of novel and effective treatments for depression.

A New Oasis in the Desert: Hope for the Depressed

This study offers a hopeful perspective on the treatment of depression, exploring the potential of glutamatergic modulators as a promising new approach. The research highlights the need for continued investigation into these novel therapies, potentially leading to the development of more effective and targeted treatments for depression.

Dr.Camel's Conclusion

This research provides a compelling case for the potential of glutamatergic modulators in treating depression. The study's findings offer a promising avenue for developing new and effective treatments, potentially improving the lives of those struggling with this debilitating condition. This research is a testament to the ongoing quest to better understand the complexities of depression and develop more effective therapies.

Date :
  1. Date Completed 2019-06-04
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29465478

DOI: Digital Object Identifier

NIHMS907111

Related Literature

Article Analysis
・Effects of dextromethorphan and quinidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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