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Multimodal lipid-lowering treatment in pediatric patients with homozygous familial hypercholesterolemia-target attainment requires further increase of intensity.

Author: BüscherRainer, DriemeyerJoenna, GalianoMatthias, HeibgesAndreas, KlausGünter, KlingelReinhard, KönigJens, OhJun, PapeLars, SchaeferJuergen R, SchmittClaus Peter, SchürfeldCarsten, SpitthöverRalf, TaylanChristina, WeberLutz T

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lipoprotein apheresis is a crucial component of lipid-lowering treatment for children with homozygous familial hypercholesterolemia, but it is not always successful in achieving LDL-C targets. Early and intensified treatment is necessary to improve outcomes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Familial hypercholesterolemia (FH) causes premature cardiovascular disease (CVD). Lipoprotein apheresis (LA) is recommended as first-line lipid-lowering treatment (LLT) for homozygous (ho) FH. METHODS: Efficacy of multimodal LLT including lifestyle counseling, drug treatment, and LA was...See full text at original site
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引用元：
https://doi.org/10.1007/s00467-018-3906-6

データ提供：米国国立医学図書館（NLM）

Treating Homozygous Familial Hypercholesterolemia: A Complex Challenge

Homozygous familial hypercholesterolemia (hoFH), a rare genetic disorder characterized by extremely high cholesterol levels, poses a significant risk of premature cardiovascular disease. This study, published in the journal [論文掲載誌], examines the effectiveness of multimodal lipid-lowering treatment (LLT) in children with hoFH.

Multimodal LLT: A Multifaceted Approach to Managing hoFH

Imagine a desert oasis where multiple sources of water are needed to sustain life. Managing hoFH requires a multifaceted approach, combining lifestyle modifications, drug therapy, and lipoprotein apheresis (LA). The researchers investigated the efficacy of this multimodal LLT approach in pediatric patients with hoFH. They found that while it effectively reduced cholesterol levels, achieving optimal target levels remained a challenge.

A Call for Intensified Treatment Strategies

This study highlights the complexities of managing hoFH and the need for intensified treatment strategies. The findings emphasize the importance of early intervention and ongoing monitoring to minimize the risk of cardiovascular disease. As Dr. Camel, I am committed to advocating for the development of more effective and accessible treatment options for patients with this challenging condition.

Dr.Camel's Conclusion

This study underscores the significant challenges faced by children with hoFH and the need for intensified multimodal LLT approaches to achieve optimal cholesterol targets. The researchers' findings highlight the importance of early intervention and ongoing research to improve treatment outcomes and minimize the risk of cardiovascular disease. As we continue to explore the vast landscape of lipid metabolism, we must strive to develop more effective treatment strategies for patients with this rare but serious condition.
Date :
  1. Date Completed 2019-10-02
  2. Date Revised 2019-10-02
Further Info :

Pubmed ID

29502162

DOI: Digital Object Identifier

10.1007/s00467-018-3906-6

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PICO Info
in preparation
Languages

English

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