Emerging roles of bexarotene in the prevention, treatment and anti-drug resistance of cancers.

Author: ChenYuanlei, ChengFeng, LiGonghui, ShenDanyang, WuYan, XiaLiqun, YuXiaoming

Paper Details 
Original Abstract of the Article :
Retinoic acid X receptors play key roles in tumor cell proliferation, differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a specific RXRs agonist which has been granted by FDA approval for the clinical treatment of cutaneous T cell lymphoma (CTCL). Its cancer pr...See full text at original site
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引用元:
https://doi.org/10.1080/14737140.2018.1449648

データ提供:米国国立医学図書館(NLM)

Bexarotene: A Versatile Weapon Against Cancer

This research delves into the fascinating world of cancer treatment, exploring the multifaceted role of bexarotene, a specific agonist for retinoic acid X receptors (RXRs). RXRs are crucial players in regulating cellular processes like proliferation, differentiation, apoptosis, and angiogenesis, making them attractive targets for cancer therapy. Bexarotene, already approved for cutaneous T cell lymphoma treatment, has emerged as a potential weapon against various cancers, exhibiting both preventive and therapeutic properties. The researchers extensively review the existing clinical trials and basic research on bexarotene, highlighting its potential applications and underlying mechanisms of action.

Bexarotene Shows Promise in Multifaceted Cancer Management

The review underscores bexarotene's potential as a potent weapon against multiple cancers, both as a preventive measure and as a therapeutic agent. The researchers highlight the potential benefits of combining bexarotene with other cytotoxic agents or targeted drugs, potentially enhancing efficacy while mitigating toxicity due to their non-overlapping side effects. However, they acknowledge that bexarotene's effectiveness may vary among patients, emphasizing the need for personalized approaches and further research to identify biomarkers for predicting response.

Navigating the Complexities of Cancer Treatment

Just as navigating a vast desert requires careful planning and understanding of the terrain, treating cancer involves a complex interplay of factors. This research provides valuable insights into the potential of bexarotene as a multifaceted cancer management tool. It reminds us that the desert of cancer research holds both challenges and opportunities, and we must continue to explore new avenues for effective and personalized treatments.

Dr.Camel's Conclusion

Bexarotene emerges as a potential force in the battle against cancer, offering a promising avenue for both prevention and treatment. Just as the desert presents both challenges and opportunities, the fight against cancer requires a multifaceted approach, and bexarotene holds the key to unlocking new possibilities.

Date :
  1. Date Completed 2019-01-03
  2. Date Revised 2019-01-03
Further Info :

Pubmed ID

29521139

DOI: Digital Object Identifier

10.1080/14737140.2018.1449648

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SNS
PICO Info
in preparation
Languages

English

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