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Emerging roles of bexarotene in the prevention, treatment and anti-drug resistance of cancers.
Author: ChenYuanlei, ChengFeng, LiGonghui, ShenDanyang, WuYan, XiaLiqun, YuXiaoming
Original Abstract of the Article :
Retinoic acid X receptors play key roles in tumor cell proliferation, differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a specific RXRs agonist which has been granted by FDA approval for the clinical treatment of cutaneous T cell lymphoma (CTCL). Its cancer pr...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1080/14737140.2018.1449648
データ提供:米国国立医学図書館(NLM)
Bexarotene: A Versatile Weapon Against Cancer
This research delves into the fascinating world of cancer treatment, exploring the multifaceted role of bexarotene, a specific agonist for retinoic acid X receptors (RXRs). RXRs are crucial players in regulating cellular processes like proliferation, differentiation, apoptosis, and angiogenesis, making them attractive targets for cancer therapy. Bexarotene, already approved for cutaneous T cell lymphoma treatment, has emerged as a potential weapon against various cancers, exhibiting both preventive and therapeutic properties. The researchers extensively review the existing clinical trials and basic research on bexarotene, highlighting its potential applications and underlying mechanisms of action.
Bexarotene Shows Promise in Multifaceted Cancer Management
The review underscores bexarotene's potential as a potent weapon against multiple cancers, both as a preventive measure and as a therapeutic agent. The researchers highlight the potential benefits of combining bexarotene with other cytotoxic agents or targeted drugs, potentially enhancing efficacy while mitigating toxicity due to their non-overlapping side effects. However, they acknowledge that bexarotene's effectiveness may vary among patients, emphasizing the need for personalized approaches and further research to identify biomarkers for predicting response.
Navigating the Complexities of Cancer Treatment
Just as navigating a vast desert requires careful planning and understanding of the terrain, treating cancer involves a complex interplay of factors. This research provides valuable insights into the potential of bexarotene as a multifaceted cancer management tool. It reminds us that the desert of cancer research holds both challenges and opportunities, and we must continue to explore new avenues for effective and personalized treatments.
Dr.Camel's Conclusion
Bexarotene emerges as a potential force in the battle against cancer, offering a promising avenue for both prevention and treatment. Just as the desert presents both challenges and opportunities, the fight against cancer requires a multifaceted approach, and bexarotene holds the key to unlocking new possibilities.
Date :
- Date Completed 2019-01-03
- Date Revised 2019-01-03
Further Info :
Related Literature
English
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