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S-allylmercaptocysteine attenuates posaconazole-induced adverse effects in mice through antioxidation and anti-inflammation.

Author: LiSiying, YangLijun, YangMin, ZhaoZhongxi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the protective effects of S-allylmercaptocysteine (SAMC) on posaconazole-induced adverse effects in mice. SAMC reduced the incidence of diarrhea, decreased pro-inflammatory cytokine levels, and improved histological changes in the colon. These findings suggest that SAMC may be a potential therapeutic agent to mitigate the adverse effects of posaconazole.
Paper Details　
Original Abstract of the Article :
Posaconazole is a broad-spectrum antibacterial drug for the treatment of invasive fungal infections. However, its clinical usage is limited by a lot of adverse reactions such as diarrhea. S-allylmercaptocysteine (SAMC), a garlic organosulfur compound, has a strong antioxidative and anti-inflammatory...See full text at original site
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引用元：
https://doi.org/10.1016/j.intimp.2018.03.006

データ提供：米国国立医学図書館（NLM）

S-allylmercaptocysteine: A Potential Solution to Posaconazole-Induced Adverse Effects

This study investigates the potential of S-allylmercaptocysteine (SAMC), a garlic organosulfur compound, to mitigate the adverse effects associated with posaconazole, a broad-spectrum antibacterial drug used to treat invasive fungal infections. The researchers examined the effects of SAMC on posaconazole-induced diarrhea in mice, highlighting the potential of this natural compound to improve drug tolerability.

SAMC to the Rescue: Mitigating Posaconazole's Adverse Effects

The study found that SAMC significantly reduced the incidence of diarrhea in mice treated with posaconazole. Furthermore, SAMC demonstrated antioxidative and anti-inflammatory properties, suggesting that it may protect against posaconazole-induced gastrointestinal damage.

Garlic's Power: A Natural Approach to Drug Tolerability

This research offers a promising natural approach to improving the tolerability of posaconazole. SAMC, a readily available compound found in garlic, could potentially be used in combination with posaconazole to minimize its adverse effects, paving the way for safer and more effective antifungal treatment.

Dr.Camel's Conclusion

Just as a desert oasis can provide relief from the harsh sun, SAMC, a compound from garlic, can offer protection from the adverse effects of posaconazole. This study provides a compelling case for further exploring the potential of natural compounds like SAMC to enhance the safety and efficacy of pharmaceutical treatments.

Date :
  1. Date Completed 2018-10-22
  2. Date Revised 2018-10-22
Further Info :

Pubmed ID

29525682

DOI: Digital Object Identifier

10.1016/j.intimp.2018.03.006

SNS
PICO Info
in preparation
Languages

English

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