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Memantine decreases neuronal degeneration in young rats submitted to LiCl-pilocarpine-induced status epilepticus.

Author: Dos SantosThainá Garbino, KalinineEduardo, MussuliniBen Hur Marins, PortelaLuis Valmor Cruz, ZenkiKamila Cagliari, ZimmerEduardo R, de OliveiraDiogo Lösch

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of memantine, a low-affinity N-methyl-d-aspartate receptor (NMDAR) channel blocker, on seizure severity and neuronal cell death in young rats with status epilepticus (SE). Memantine was neuroprotective against SE-induced neuronal death, and this neuroprotection was time- and region-dependent.
Paper Details　
Original Abstract of the Article :
Several works have demonstrated that status epilepticus (SE) induced-neurodegeneration appears to involve an overactivation of N-methyl-d-aspartate receptors and treatment with high-affinity NMDAR antagonists is neuroprotective against this brain damage. However, these compounds display undesirable ...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuro.2018.03.005

データ提供：米国国立医学図書館（NLM）

Memantine: A Protective Oasis in the Storm of Epilepsy

Epilepsy, a neurological disorder characterized by seizures, can be a frightening experience, like a storm raging through a once-peaceful desert. This study investigates the potential of memantine, a drug that blocks certain brain receptors, for protecting against neuronal damage caused by seizures in young rats.

The researchers induced seizures in young rats and tested the effects of memantine on reducing seizure severity and neuronal damage. The results suggest that memantine, when administered at specific times, can significantly reduce neuronal death in the brain regions affected by seizures. This finding highlights the potential of memantine as a neuroprotective agent in epilepsy.

Navigating the Epilepsy Storm: Memantine as a Potential Shield

This study provides evidence that memantine may offer a protective shield against neuronal damage caused by seizures. This finding is particularly promising for managing epilepsy in young individuals, where brain development is highly vulnerable to the damaging effects of seizures. The research underscores the need for further investigations into the therapeutic potential of memantine in epilepsy.

Finding Shelter: Protecting the Brain from the Storms of Epilepsy

The potential of memantine to protect against neuronal damage caused by seizures offers a glimmer of hope for improving the long-term outcomes of patients with epilepsy. This research encourages further studies into the use of memantine in managing this debilitating neurological disorder.

Dr.Camel's Conclusion

This study explores the potential of memantine to protect against neuronal damage caused by seizures in young rats. The findings highlight the importance of timing in administering memantine to maximize its protective effects. This research offers a potential oasis of hope for individuals battling epilepsy, a condition that can have a profound impact on brain health and quality of life.

Date :
  1. Date Completed 2019-03-21
  2. Date Revised 2019-03-21
Further Info :

Pubmed ID

29545205

DOI: Digital Object Identifier

10.1016/j.neuro.2018.03.005

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in preparation
Languages

English

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