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Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials.

Author: PermsuwanUnchalee, SirichanchuenBuntitabhon, SriutthaPajaree

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Diclofenac may be associated with a higher risk of hepatotoxicity compared to other nonsteroidal anti-inflammatory drugs (NSAIDs).
Paper Details　
Original Abstract of the Article :
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medication in several countries, including Thailand. NSAIDs have been associated with hepatic side effects; however, the frequency of these side effects is uncertain. AIM OF THE REVIEW: To systematically review publi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820561/

データ提供：米国国立医学図書館（NLM）

Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs

This research systematically reviews randomized controlled trials to assess the risk of clinically significant hepatotoxicity associated with nonsteroidal anti-inflammatory drugs (NSAIDs). The study reviewed 18 studies examining the hepatotoxicity of various NSAIDs, including ibuprofen, naproxen, diclofenac, piroxicam, meloxicam, mefenamic acid, indomethacin, celecoxib, and etoricoxib. The analysis revealed that diclofenac had the highest proportion of hepatotoxic evidence, primarily in the form of elevated aminotransferase levels, while other NSAIDs demonstrated lower rates of clinically significant hepatotoxicity.

NSAIDs: Balancing Benefits and Risks

This research highlights the importance of considering the potential risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs). While NSAIDs are widely used for pain relief, the study found that diclofenac, a commonly prescribed NSAID, has a higher risk of hepatotoxicity. This information is crucial for healthcare professionals to make informed decisions about prescribing NSAIDs and for patients to understand the potential side effects of these medications.

Navigating Pain Relief

NSAIDs can be helpful for pain management, but it's important to be aware of their potential side effects, including hepatotoxicity. This research suggests that diclofenac may have a higher risk than some other NSAIDs. If you're taking NSAIDs, it's essential to discuss any concerns with your doctor and make sure you are receiving the most appropriate treatment for your pain. Remember, understanding the risks and benefits of medications is crucial for managing your health effectively.

Dr.Camel's Conclusion

This systematic review provides a comprehensive analysis of the hepatotoxicity associated with various NSAIDs. The findings highlight the importance of considering the potential risks of NSAIDs, particularly diclofenac, which showed a higher proportion of hepatotoxic evidence.
Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

29568654

DOI: Digital Object Identifier

PMC5820561

SNS
PICO Info
in preparation
Languages

English

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