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Prevalence of Pyrazinamide Resistance in Khyber Pakhtunkhwa, Pakistan.

Author: AfzalMuhammad Tanvir, AliSajid, KhanMuhammad Tahir, MalikShaukat Iqbal, MasoodNayyer, NadeemTariq, Sheed KhanAnwar, ZebMuhammad Tariq

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Pyrazinamide (PZA) is crucial in TB treatment. This study aimed to assess the prevalence of PZA resistance in Pakistan, especially in the Khyber Pakhtunkhwa province, and its relationship with resistance to other TB drugs.
Paper Details　
Original Abstract of the Article :
Pyrazinamide (PZA) is an important component of first-line tuberculosis (TB) treatment because of its distinctive capability to kill subpopulations of persister Mycobacterium tuberculosis (MTB). The significance of PZA can be understood by its inclusion in the most recent World Health Organization-r...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1089/mdr.2017.0234

データ提供：米国国立医学図書館（NLM）

Pyrazinamide Resistance: A Threat in the Desert of Tuberculosis Treatment

This research takes us on a journey into the complex world of tuberculosis (TB) treatment, a field that can be as challenging to navigate as a vast and unforgiving desert. The researchers investigated the prevalence of pyrazinamide resistance in Khyber Pakhtunkhwa (KPK), Pakistan, a region known for its high burden of TB. They analyzed data on drug susceptibility testing (DST) to determine the extent of pyrazinamide resistance in the region and its correlation with resistance to other first- and second-line drugs.

Pyrazinamide Resistance: A Growing Challenge

This study highlights the growing threat of pyrazinamide resistance in Khyber Pakhtunkhwa, Pakistan. The researchers found a significant prevalence of pyrazinamide resistance in the region, highlighting the need for enhanced surveillance and effective treatment strategies to combat this growing challenge. This finding is particularly concerning because pyrazinamide is a key component of first-line TB treatment.

Tuberculosis Treatment: Navigating a Complex Landscape

The treatment of TB can be a lengthy and complex process, often requiring multiple medications and careful monitoring. This study underscores the importance of understanding and addressing drug resistance to ensure effective treatment and prevent the spread of resistant strains. It emphasizes the need for continued research to develop new and effective treatments for drug-resistant TB.

Dr.Camel's Conclusion

This study provides a valuable analysis of the prevalence of pyrazinamide resistance in Khyber Pakhtunkhwa, Pakistan, highlighting the importance of addressing this growing challenge in the fight against tuberculosis. The findings underscore the need for enhanced surveillance, effective treatment strategies, and ongoing research to develop new and effective treatments for drug-resistant TB. It serves as a reminder that the battle against TB is a relentless journey, demanding continuous vigilance and innovation.

Date :
  1. Date Completed 2019-01-30
  2. Date Revised 2019-01-30
Further Info :

Pubmed ID

29584579

DOI: Digital Object Identifier

10.1089/mdr.2017.0234

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Languages

English

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