Safety data and withdrawal of hepatotoxic drugs.

Author: AuclertLaurent, BabaiSamy, Le-LouëtHervé

Paper Details 
Original Abstract of the Article :
The occurrence of drug induced liver injury (DILI) is the most common reason of post-marketing withdrawals. DILI in humans is difficult to predict using in vitro cytotoxicity screening and animal studies. A review of hepatotoxicity data was performed with the aim of identifying relevant factors that...See full text at original site
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引用元:
https://doi.org/10.1016/j.therap.2018.02.004

データ提供:米国国立医学図書館(NLM)

Drug-Induced Liver Injury: A Silent Threat in Drug Development

This study focuses on the critical issue of drug-induced liver injury (DILI), a serious side effect that can occur with certain medications. The researchers reviewed data on hepatotoxicity (liver toxicity) to understand the factors that might predict DILI and identify potential strategies for minimizing its occurrence.

The study highlights the challenge of predicting DILI in humans, as traditional methods like in vitro testing and animal studies often fail to capture the full complexity of liver toxicity. This is like navigating a desert with a map that doesn't accurately reflect the hidden dangers beneath the sand. It emphasizes the need for more sophisticated and predictive methods for assessing drug safety.

Improving Drug Safety

This study underscores the importance of careful drug development and monitoring to minimize the risk of DILI. Early identification and understanding of potential hepatotoxins are crucial for ensuring drug safety and protecting patients from serious harm.

Prioritizing Liver Health

Maintaining liver health is vital for overall well-being. It's important to avoid excessive alcohol consumption, maintain a healthy weight, and consult with a doctor about any medications you are taking.

Dr.Camel's Conclusion

This research delves into the often-hidden dangers of drug-induced liver injury. Like a camel navigating a desert with unpredictable sandstorms, researchers are seeking ways to predict and prevent this serious side effect. The study highlights the ongoing need for vigilance in drug development and the importance of understanding the potential impact of medications on liver health.

Date :
  1. Date Completed 2021-11-23
  2. Date Revised 2021-11-23
Further Info :

Pubmed ID

29609830

DOI: Digital Object Identifier

10.1016/j.therap.2018.02.004

SNS
PICO Info
in preparation
Languages

English

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