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Immune response to the hepatitis B antigen in the RTS,S/AS01 malaria vaccine, and co-administration with pneumococcal conjugate and rotavirus vaccines in African children: A randomized controlled trial.

Author: AdjeiSamuel, AgbenyegaTsiri, AnsongDaniel, BorysDorota, BuabengPatrick, HabibMd Ahsan, IdrissAli, JongertErik, KoteyAmos, LeachAmanda, LievensMarc, LompoPalpouguini, Mwinessobaonfou SomeAthanase, NanaLouis Arnaud, OuedraogoFlorence, OuedraogoSayouba, Owusu BoatengHarry, PrempehFrank, RettigTheresa, SambianDavid, SchuermanLode, SorghoHermann, TahitaMarc Christian, TintoHalidou, TraoreOusmane, UsufEffua, ValéaInnocent, VandoolaeghePascale, VekemansJohan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the immunogenicity and safety of co-administering the RTS,S/AS01 malaria vaccine with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and human rotavirus vaccine (HRV) in African infants. Co-administration with RTS,S/AS01 did not compromise the immunogenicity of the co-administered vaccines, meeting non-inferiority criteria for PHiD-CV, HRV, and pertussis antigens. While some adverse events, such as pain and low-grade fever, were more frequent in the PHiD-CV group, no serious adverse events were considered vaccine-related. The study suggests that co-administering RTS,S/AS01 with pediatric vaccines is safe and immunologically acceptable.
Paper Details　
Original Abstract of the Article :
The RTS,S/AS01 malaria vaccine (Mosquirix) reduces the incidence of Plasmodium falciparum malaria and is intended for routine administration to infants in Sub-Saharan Africa. We evaluated the immunogenicity and safety of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037440/

データ提供：米国国立医学図書館（NLM）

Evaluating the Immunogenicity and Safety of Co-administered Vaccines

The RTS,S/AS01 malaria vaccine, a potential game-changer in the fight against malaria, holds promise for protecting children in malaria-prone regions. This research investigates the immunogenicity and safety of co-administering RTS,S/AS01 with other commonly used pediatric vaccines, a crucial step in optimizing vaccination strategies for children. The study, a randomized controlled trial, examined the immune responses to hepatitis B vaccine (HBV), pneumococcal conjugate vaccine (PHiD-CV), and rotavirus vaccine (HRV) when co-administered with RTS,S/AS01 in African infants, seeking to ensure the safety and efficacy of these important vaccines. The findings offer valuable insights into the feasibility and effectiveness of co-administering these vaccines, a significant step towards improving childhood immunization in this vulnerable population.

Co-administered Vaccines: A Promising Strategy for Childhood Immunization

The study found that co-administering RTS,S/AS01 with HBV, PHiD-CV, and HRV did not negatively impact the immunogenicity of these vaccines. Furthermore, the study demonstrated that RTS,S/AS01 induced a response to circumsporozoite protein, a key component of the malaria parasite. These findings suggest that co-administering these vaccines is a safe and effective strategy for improving childhood immunization in malaria-prone regions, a crucial step in protecting children from these devastating diseases. The study's findings offer a glimmer of hope in the fight against malaria and other preventable childhood diseases.

Navigating the Desert of Childhood Immunization: Optimizing Vaccine Strategies

The study's findings underscore the importance of optimizing vaccination strategies for children, a critical step in ensuring their health and well-being. Co-administering RTS,S/AS01 with other commonly used pediatric vaccines offers a potential solution for improving immunization coverage and reducing the burden of preventable diseases. Further research is needed to refine these co-administration strategies and to assess their long-term effectiveness in diverse populations. This study serves as a valuable guidepost in navigating the desert of childhood immunization, helping us to create a healthier future for children worldwide.

Dr. Camel's Conclusion

This study provides encouraging evidence for the feasibility and effectiveness of co-administering RTS,S/AS01 with other pediatric vaccines, a potential game-changer in the fight against malaria and other preventable childhood diseases. Further research is needed to optimize these co-administration strategies, but this study offers a valuable beacon of hope in the quest for better childhood immunization programs.

Date :
  1. Date Completed 2019-01-28
  2. Date Revised 2019-01-28
Further Info :

Pubmed ID

29630438

DOI: Digital Object Identifier

PMC6037440

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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