A Focus on Macitentan in the Treatment of Pulmonary Arterial Hypertension.

Author: BedanMartin, GrimmDaniela, InfangerManfred, KrügerMarcus, SimonsenUlf, WehlandMarkus

Paper Details 
Original Abstract of the Article :
The approval of macitentan has increased the number of pharmacological treatments of pulmonary arterial hypertension (PAH). Here, we review the effect on PAH of macitentan compared to other endothelin receptor antagonists. Drugs targeting the endothelin (ET) pathway include the selective ET<sub>A</s...See full text at original site
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引用元:
https://doi.org/10.1111/bcpt.13033

データ提供:米国国立医学図書館(NLM)

Macitentan: A New Hope for Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a serious and life-threatening condition that affects the arteries in the lungs. This research investigates the role of macitentan, a recently approved medication, in the treatment of PAH. The authors compare macitentan with other endothelin receptor antagonists, a class of drugs that target the endothelin pathway involved in blood vessel constriction.

Macitentan: A Rising Star in PAH Treatment

The study highlights the promising efficacy of macitentan in managing PAH. It demonstrates that macitentan exhibits greater potency than other endothelin receptor antagonists and has a longer duration of action. The results from clinical trials indicate that macitentan significantly improves exercise capacity and reduces morbidity and mortality in PAH patients. Furthermore, the study suggests that macitentan may have a lower risk of side effects such as peripheral edema and hepatotoxicity compared to other endothelin receptor antagonists.

A New Era of PAH Management

This research paves the way for a new era of PAH management. Macitentan offers a valuable treatment option with a favorable safety profile and demonstrated efficacy in improving the lives of PAH patients. The study encourages further research to explore the long-term benefits and optimal use of macitentan in combination with other PAH therapies.

Dr.Camel's Conclusion

Just as a camel navigates the desert with its enduring strength, macitentan provides a durable and effective treatment for PAH. This research offers hope for patients with PAH, showcasing a new horizon in the management of this challenging condition.

Date :
  1. Date Completed 2018-10-24
  2. Date Revised 2019-09-17
Further Info :

Pubmed ID

29719121

DOI: Digital Object Identifier

10.1111/bcpt.13033

Related Literature

SNS
PICO Info
in preparation
Languages

English

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