Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine.

Author: BarbieriAntonio, CoppolaCarmela, De LorenzoClaudia, MaureaNicola, PacielloRolando, ReaDomenica, RiccioGennaro

Paper Details 
Original Abstract of the Article :
Pertuzumab, a novel anti-epidermal growth factor receptor 2 humanized monoclonal antibody, and trastuzumab-emtansine (TDM1), a novel antibody-drug conjugate made up of trastuzumab covalently linked to the highly potent microtubule inhibitory agent DM1, have been recently approved by the US Food and ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914739/

データ提供:米国国立医学図書館(NLM)

Cardiotoxic Effects of Novel Anti-ErbB2 Agents and Ranolazine's Cardioprotective Potential

The development of new therapies for [breast cancer] is a continuous pursuit, aiming to improve both efficacy and safety. This research investigates the cardiotoxic effects of two novel anti-ErbB2 agents, pertuzumab and trastuzumab-emtansine (TDM1), and explores the potential cardioprotective effects of ranolazine. The study found that both pertuzumab and TDM1 exhibited potential cardiotoxic effects, highlighting the need for careful monitoring of cardiac function in patients receiving these therapies. However, the study also demonstrated that ranolazine could potentially mitigate the cardiotoxic effects of these agents, offering a potential strategy for minimizing cardiac complications.

Balancing Efficacy and Safety in Breast Cancer Treatment

This research underscores the importance of considering both efficacy and safety when developing new breast cancer therapies. The study identified potential cardiotoxic effects of two novel anti-ErbB2 agents, pertuzumab and TDM1, highlighting the need for careful monitoring of cardiac function in patients receiving these therapies. However, the study also demonstrated the potential of ranolazine to mitigate these cardiotoxic effects, offering a potential strategy for minimizing cardiac complications and enhancing the safety profile of these valuable cancer treatments.

Navigating the Desert of Breast Cancer Treatment

Breast cancer treatment can feel like a long and arduous journey across a vast desert, with potential side effects and complications to overcome. This research provides valuable insights into the cardiotoxic effects of novel anti-ErbB2 agents, highlighting the importance of monitoring cardiac function and exploring potential strategies for mitigating these risks. By understanding the complexities of these therapies, we can navigate the desert of breast cancer treatment with greater confidence and safety.

Dr.Camel's Conclusion

This research, like a camel navigating a desert oasis, explores the delicate balance between efficacy and safety in breast cancer treatment. By understanding the potential cardiotoxic effects of novel anti-ErbB2 agents and investigating strategies for mitigating these risks, we can guide patients toward a more comfortable and safe journey through the desert of breast cancer treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

29719406

DOI: Digital Object Identifier

PMC5914739

Related Literature

SNS
PICO Info
in preparation
Languages

English

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