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Cardiotoxic effects of the novel approved anti-ErbB2 agents and reverse cardioprotective effects of ranolazine.
Author: BarbieriAntonio, CoppolaCarmela, De LorenzoClaudia, MaureaNicola, PacielloRolando, ReaDomenica, RiccioGennaro
Original Abstract of the Article :
Pertuzumab, a novel anti-epidermal growth factor receptor 2 humanized monoclonal antibody, and trastuzumab-emtansine (TDM1), a novel antibody-drug conjugate made up of trastuzumab covalently linked to the highly potent microtubule inhibitory agent DM1, have been recently approved by the US Food and ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914739/
データ提供:米国国立医学図書館(NLM)
Cardiotoxic Effects of Novel Anti-ErbB2 Agents and Ranolazine's Cardioprotective Potential
The development of new therapies for [breast cancer] is a continuous pursuit, aiming to improve both efficacy and safety. This research investigates the cardiotoxic effects of two novel anti-ErbB2 agents, pertuzumab and trastuzumab-emtansine (TDM1), and explores the potential cardioprotective effects of ranolazine. The study found that both pertuzumab and TDM1 exhibited potential cardiotoxic effects, highlighting the need for careful monitoring of cardiac function in patients receiving these therapies. However, the study also demonstrated that ranolazine could potentially mitigate the cardiotoxic effects of these agents, offering a potential strategy for minimizing cardiac complications.
Balancing Efficacy and Safety in Breast Cancer Treatment
This research underscores the importance of considering both efficacy and safety when developing new breast cancer therapies. The study identified potential cardiotoxic effects of two novel anti-ErbB2 agents, pertuzumab and TDM1, highlighting the need for careful monitoring of cardiac function in patients receiving these therapies. However, the study also demonstrated the potential of ranolazine to mitigate these cardiotoxic effects, offering a potential strategy for minimizing cardiac complications and enhancing the safety profile of these valuable cancer treatments.
Navigating the Desert of Breast Cancer Treatment
Breast cancer treatment can feel like a long and arduous journey across a vast desert, with potential side effects and complications to overcome. This research provides valuable insights into the cardiotoxic effects of novel anti-ErbB2 agents, highlighting the importance of monitoring cardiac function and exploring potential strategies for mitigating these risks. By understanding the complexities of these therapies, we can navigate the desert of breast cancer treatment with greater confidence and safety.
Dr.Camel's Conclusion
This research, like a camel navigating a desert oasis, explores the delicate balance between efficacy and safety in breast cancer treatment. By understanding the potential cardiotoxic effects of novel anti-ErbB2 agents and investigating strategies for mitigating these risks, we can guide patients toward a more comfortable and safe journey through the desert of breast cancer treatment.
Date :
- Date Completed n.d.
- Date Revised 2022-03-17
Further Info :
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