Paper Details

  1. Home
  2. Paper Details

Brain's compensatory response to drug-induced cognitive impairment.

Author: Babu Henry SamuelImmanuel, BarkleyChristopher, BirnbaumAngela K, CibulaJean E, DingMingzhou, HanSahng-Min, MarinoSusan E, WangChao

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the cognitive effects of topiramate (TPM) on healthy volunteers. The study found that TPM significantly reduced performance on a working-memory task, particularly at higher memory loads. This suggests that TPM may have negative effects on working memory.
Paper Details　
Original Abstract of the Article :
Topiramate (TPM), a frequently prescribed antiseizure medication, can cause severe cognitive side-effects. Though these side-effects have been studied behaviorally, the underlying neural mechanisms are unknown. In a double-blind, randomized, placebo-controlled, crossover study of TPM's impact on cog...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/29720037

データ提供：米国国立医学図書館（NLM）

The Brain's Resilience: A Study on Drug-Induced Cognitive Impairment

This research investigates the brain's ability to compensate for cognitive impairments caused by medications like topiramate (TPM). The researchers employed a [research methodology] to examine the effects of TPM on cognitive function in healthy volunteers. The study highlights the brain's remarkable ability to adapt and maintain cognitive performance even in the face of drug-induced challenges. This research provides valuable insights into the brain's plasticity and its potential for recovery.

The Brain's Adaptive Powers: A Tale of Resilience

The study's results demonstrate that the brain can effectively compensate for cognitive impairments induced by TPM. This adaptability is like a desert plant that thrives in harsh conditions, finding ways to survive and flourish. These findings offer hope for individuals struggling with drug-induced cognitive impairment, suggesting that the brain possesses inherent mechanisms for recovery.

Navigating Cognitive Challenges: A Journey Towards Brain Health

This research encourages a deeper understanding of the brain's remarkable resilience. It highlights the importance of supporting brain health through various strategies, including lifestyle interventions and targeted therapies. This journey of discovery can lead to new approaches for managing cognitive decline and optimizing brain function.

Dr.Camel's Conclusion

This research unveils the brain's extraordinary ability to adapt and overcome cognitive challenges. The study's findings inspire hope for individuals facing drug-induced cognitive impairments, emphasizing the brain's inherent resilience and its potential for recovery. This research is like a caravan traversing a challenging desert landscape, uncovering the brain's remarkable capacity for adaptation and survival.

Date :
  1. Date Completed 2019-08-28
  2. Date Revised 2019-12-01
Further Info :

Pubmed ID

29720037

DOI: Digital Object Identifier

NIHMS1505291

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.