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Polyamine-Targeting Gefitinib Prodrug and its Near-Infrared Fluorescent Theranostic Derivative for Monitoring Drug Delivery and Lung Cancer Therapy.

Author: ChenLingxin, HanXiaoyue, LvChangjun, SongXinyu, YuFabiao, ZhangXiaoyu

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the development of PPG, a tumor-targeting prodrug for the precision therapy of non-small-cell lung cancer (NSCLC). PPG efficiently delivers the anti-tumor drug to cancer cells, reducing side effects on normal cells. It was effective in killing Gefitinib-sensitive PC9 cells and inhibiting the growth of Gefitinib-resistant H1650 cells. The study also developed TPG, an activatable fluorescent theranostics, for real-time monitoring of prodrug delivery and diagnosis of lung cancer.
Paper Details　
Original Abstract of the Article :
The therapy of non-small-cell lung cancer (NSCLC) is challenging because of poor prognosis. There are urgent demands for targeting anti-tumor drugs with reliable efficacy and clear pharmacokinetics. <b>Methods</b>: We designed and synthesized an active tumor-targeting prodrug for the precision thera...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928882/

データ提供：米国国立医学図書館（NLM）

Polyamine-Targeting Gefitinib Prodrug: A New Oasis in Lung Cancer Treatment

This research explores the development of a novel polyamine-targeting Gefitinib prodrug (PPG) for treating non-small-cell lung cancer (NSCLC). It's like discovering a hidden oasis in the desert of lung cancer, offering a new and promising treatment approach. The authors, like ingenious desert engineers, meticulously design and synthesize PPG, combining a tumor-targeting polyamine analog (PA) with Gefitinib, a tyrosine kinase inhibitor. The study demonstrates the potential of PPG to target cancer cells with high efficacy and minimal side effects, offering a more precise and effective way to combat NSCLC.

Precision Targeting in the Desert: A New Weapon Against Lung Cancer

This study highlights the potential of PPG to effectively target NSCLC cells, offering a more precise and potentially more effective treatment option. The authors demonstrate the ability of PPG to deliver Gefitinib directly to cancer cells, minimizing the drug's impact on healthy tissues. It's like finding a guided missile that precisely targets the source of a desert fire, minimizing collateral damage.

Navigating the Desert of Lung Cancer: A New Path to Recovery

This research underscores the promise of personalized medicine for treating NSCLC. The study suggests that PPG, with its targeted delivery system, has the potential to significantly improve treatment outcomes, offering hope for patients facing this challenging disease. It's like finding a new path through a desert, leading to a safer and more effective journey towards recovery.

Dr.Camel's Conclusion

This research offers a promising new approach to treating NSCLC, highlighting the potential of a polyamine-targeting Gefitinib prodrug (PPG) to precisely target cancer cells with high efficacy and minimal side effects. It's like discovering a hidden oasis in the desert of lung cancer, offering hope for a more effective and personalized approach to treatment.
Date :
  1. Date Completed 2019-04-08
  2. Date Revised 2019-10-23
Further Info :

Pubmed ID

29721074

DOI: Digital Object Identifier

PMC5928882

Related Literature

Article Analysis
・Side Effects of gefitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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