The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.

Author: AhmadiNeeki, AmdurRichard L, DominguesCleyton C, DoreFiona J, HoustonSara, KhiyamiAnamil, KropotovaYana, KunduNabanita, MammadovaAytan, RouphaelCarol, SenSabyasachi, WitkinLinda

Paper Details 
Original Abstract of the Article :
Type 2 diabetes is associated with endothelial dysfunction leading to cardiovascular disease. CD34+ endothelial Progenitor Cells (EPCs) are responsible for endothelial repair and neo-angiogenesis and can be used as a cardiovascular disease risk biomarker. This study investigated whether the addition...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934787/

データ提供:米国国立医学図書館(NLM)

Saxagliptin and Metformin: A Synergistic Approach to Diabetes Management

This study examines the potential of saxagliptin, a DPP-IV inhibitor, and metformin, a commonly prescribed diabetes medication, in managing type 2 diabetes. It's like a desert expedition, exploring new strategies to combat the challenges of this chronic disease.

Protecting Against Cardiovascular Disease

The researchers investigated the impact of combining saxagliptin with metformin on CD34+ endothelial progenitor cells, key players in endothelial repair and cardiovascular health. It's like discovering a hidden spring of vitality, nurturing the body's natural defenses. The findings suggest that this combination therapy may offer additional cardiovascular benefits beyond glycemic control.

A Promising Therapeutic Strategy

This study provides evidence that combining saxagliptin with metformin could be a promising approach to reducing cardiovascular risk in type 2 diabetes patients. It's like finding a new oasis in the desert of diabetes management, offering hope for improved long-term health.

Dr. Camel's Conclusion

This study emphasizes the importance of finding innovative approaches to combat the challenges of type 2 diabetes. It's like a desert traveler seeking the most efficient and effective route to reach a destination. The research suggests that combining saxagliptin with metformin could be a valuable tool for managing this complex disease and protecting against cardiovascular complications.

Date :
  1. Date Completed 2019-01-28
  2. Date Revised 2023-11-12
Further Info :

Pubmed ID

29724198

DOI: Digital Object Identifier

PMC5934787

Related Literature

SNS
PICO Info
in preparation
Languages

English

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